ArticleThe International journal of eating disorders2017
Impact of low-weight severity and menstrual status on bone in adolescent girls with anorexia nervosa.
Article in The International journal of eating disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- 2025 Update to the Female Athlete Triad Coalition Consensus Statement Part 2: Clinical Guidelines for Screening, Diagnosis, Treatment, and Return to Play for Adolescents and Adults.Sports medicine (Auckland, N.Z.) · 2026Guideline
- Restrictive eating disorders in higher weight persons: A systematic review of atypical anorexia nervosa prevalence and consecutive admission literature.The International journal of eating disorders · 2021Pooled it
- Dual-energy X-ray absorptiometry per cent fat Z-score as a predictor of menstrual status in adolescent and young adult female athletes.British journal of sports medicine · 2026Article
- 2025 Update to the Female Athlete Triad Coalition Consensus Statement Part 1: State of the Science and Introduction of a New Adolescent Model.Sports medicine (Auckland, N.Z.) · 2026Review
- Associations between bone mineral density, body composition and amenorrhoea in females with eating disorders: a systematic review and meta-analysis.Journal of eating disorders · 2022Review
- Functional hypothalamic amenorrhea: Impact on bone and neuropsychiatric outcomes.Frontiers in endocrinology · 2022Review
- Absence of relationships between depression and anxiety and bone mineral density in patients hospitalized for severe anorexia nervosa.Eating and weight disorders : EWD · 2021Article
- Some of the burden of eating disorders is still hidden.The lancet. Psychiatry · 2021Article
- Changes in appetite-regulating hormones following food intake are associated with changes in reported appetite and a measure of hedonic eating in girls and young women with anorexia nervosa.Psychoneuroendocrinology · 2020Article
- Mental, behavioral and neurodevelopmental disorders in the ICD-11: an international perspective on key changes and controversies.BMC medicine · 2020Article
- [Fractures and bone mineral density in childhood].Zeitschrift fur Rheumatologie · 2019Review
- The Ghrelin-AgRP Neuron Nexus in Anorexia Nervosa: Implications for Metabolic and Behavioral Adaptations.Frontiers in nutrition · 2019Review
- Anorexia Nervosa and Bone.Current opinion in endocrine and metabolic research · 2018Article
- Eating disorders and bone metabolism in women.Current opinion in pediatrics · 2017Review
Corrections and comments
- Erratum issued
Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
Clinicians currently use different low-weight cut-offs both to diagnose anorexia nervosa (AN) and to determine AN severity in adolescent girls. The purpose of this study was to evaluate the clinical utility of existing cut-offs and severity criteria by determining which are most strongly associated with risk for low bone mineral density (BMD). Height adjusted BMD Z scores were calculated for 352 females: 262 with AN and 90 healthy controls (controls) (12-20.5 years), using data from the BMD in Childhood Study, for the lumbar spine, whole body less head, and total hip. For most cut-offs used to define low weight (5th or 10th BMI percentile, BMI of 17.5 or 18.5, and 85 or 90% of median BMI), AN had lower BMD Z scores than controls. AN at >85 or >90% expected body weight for height (EBW-Ht) did not differ in BMD Z scores from controls, but differed significantly from AN at ≤85 or ≤90% EBW-Ht. Among AN, any amenorrhea was associated with lower BMD. AN had lower BMD than controls across DSM-5 and The Society for Adolescent Health and Medicine (SAHM) severity categories. The SAHM moderate severity classification was differentiated from the mildly malnourished classification by lower BMD at hip and spine sites. Amenorrhea and %EBW-Ht ≤ 85 or ≤ 90% are markers of severity of bone loss within AN. Among severity categories, BMI Z scores (SAHM) may have the greatest utility in assessing the degree of malnutrition in adolescent girls that corresponds to lower BMD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.