Evidence map›Paper›PMID 28152160›Full record

ArticleJournal of the American Geriatrics Society2017

New or Worsening Symptoms and Signs in Community-Dwelling Persons with Dementia: Incidence and Relation to Use of Acute Medical Services.

Philip D Sloane, Christopher H Schifeling, Anna S Beeber, Kimberly T Ward, David Reed, Lisa P Gwyther, Bobbi Matchar, Sheryl Zimmerman

Abstract read
In one paragraph

Article in Journal of the American Geriatrics Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Using Natural Language Processing to Identify Home Health Care Patients at Risk for Diagnosis of Alzheimer's Disease and Related Dementias.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Philip D SloaneDepartment of Family Medicine, School of Medicine, Denver, Colorado.
Christopher H SchifelingDepartment of Medicine, University of Colorado School of Medicine, Denver, Colorado.
Anna S BeeberDepartment of Medicine, University of Colorado School of Medicine, Denver, Colorado.
Kimberly T WardDepartment of Medicine, University of Colorado School of Medicine, Denver, Colorado.
David ReedDepartment of Medicine, University of Colorado School of Medicine, Denver, Colorado.
Lisa P GwytherDuke Family Support Program, Duke University, Durham, North Carolina.
Bobbi MatcharDuke Family Support Program, Duke University, Durham, North Carolina.
Sheryl ZimmermanDepartment of Medicine, University of Colorado School of Medicine, Denver, Colorado.

Funding

Alzheimers Medical Advisor: A Symptom and Sign Management Toolkit for CaregiversR01NR014199 · NINR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SLOANE, PHILIP D · 2012 to 2016
$2.5M
UNC-CH Summer Research Training in Aging for Medical StudentsT35AG038047 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JAN BUSBY-WHITEHEAD · 2010 to 2026
$1.4M
NIA NIH HHS T35 AG038047NINR NIH HHS R01 NR014199
6 · The paper itself

Abstract

objectivesTo understand the range of symptoms that present to family caregivers of community-dwelling persons with Alzheimer's disease and related dementias (ADRD).

designSix-month longitudinal prospective study to identify the incidence of new or worsening symptoms and their association with acute care medical service use.

settingCommunity-based sample of volunteers from multiple states.

participantsA total of 136 patient-caregiver dyads with a range of dementia severity. MEASUREMENTS: Forty four symptoms and signs common in older persons and/or persons with dementia; frequency of emergency department visits, hospitalizations, and death; and associations between reported symptoms and acute medical care.

resultsDuring a mean of 5.7 months' follow-up, new or worsening organ-specific (90% of participants), nonspecific (89%), and behavioral (88%) symptoms were common, with the average caregiver reporting seven new or worsening symptoms. Most common were worsening confusion (74%), decreased activity (64%), agitation (57%), hallucinations/delusions (45%), voice and speaking problems (45%), not eating or drinking (44%), and stress/anxiety (41%). Hospitalization and emergency department use occurred respectively in 19% and 20% of participants, and were associated with organ-specific symptoms (OR 3.15, P = .02), less so with nonspecific symptoms (OR 2.27, P = .07), and very little with behavioral symptoms (OR 1.44, P = .38). Within each symptom category, certain symptoms were significantly associated with acute medical service use.

conclusionFamily caregivers of persons with ADRD must respond to a variety of medical, nonspecific, and behavioral symptoms. The high incidence of new or worsening symptoms and of acute medical care use suggests a need to better target symptom evaluation and management in caregiver education.

Indexed as

Independent LivingPatient Acceptance of Health CareAcute DiseaseAgedCaregiversDementiaFemaleHumansIncidenceLongitudinal StudiesMaleProspective Studiescommunity dwellingcomorbiditydementiasymptoms

Identifiers

PMID28152160
PMCPMC5397340

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.