ArticlePloS one2017
Inhibitory activity of hinokitiol against biofilm formation in fluconazole-resistant Candida species.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 44 citations in OpenAlex.
- Novel Hinokitiol-Based Ester/Sulfonate Derivatives Containing Diverse Heterocycles as Potential Fungicides and Nematicides.Chemistry & biodiversity · 2026Article
- Berberine Interferes with the Molecular Landscape of Biofilm-Driven Pathogenicity.Pathogens (Basel, Switzerland) · 2026Review
- Physical Properties of New Silica-Based Denture Surface Coating.Nanomaterials (Basel, Switzerland) · 2025Article
- Myricetin Exerts Antibiofilm Effects onJournal of fungi (Basel, Switzerland) · 2025Article
- Natural Compounds with Antifungal Properties againstAntibiotics (Basel, Switzerland) · 2023Article
- Inhibitory effects of hinokitiol on the development and pathogenicity of Colletotrichum gloeosporioides.World journal of microbiology & biotechnology · 2023Article
- Antimicrobial surface processing of polymethyl methacrylate denture base resin using a novel silica-based coating technology.Clinical oral investigations · 2023Article
- Hinokitiol inhibitsFrontiers in microbiology · 2023Article
- Antimicrobial effect of oral care gel containing hinokitiol and 4-isopropyl-3-methylphenol against intraoral pathogenic microorganisms.PloS one · 2023Article
- The Cytotoxic and Inhibitory Effects of Plant Derivatives onMolecules (Basel, Switzerland) · 2022Article
- Effects ofAntibiotics (Basel, Switzerland) · 2022Article
- Ethanolic extract ofFrontiers in cellular and infection microbiology · 2022Article
- Hinokitiol chelates intracellular iron to retard fungal growth by disturbing mitochondrial respiration.Journal of advanced research · 2021Article
- Synthesis and Physicochemical Characterization of Novel Dicyclopropyl-Thiazole Compounds as Nontoxic and Promising Antifungals.Materials (Basel, Switzerland) · 2021Article
- Cotreatment with Aspirin and Azole Drugs Increases Sensitivity ofInfection and drug resistance · 2021Article
- Insight into the Antifungal Mechanism of Action of Human RNase N-terminus Derived Peptides.International journal of molecular sciences · 2019Article
- Biofilm Formation and Resistance to Fungicides in Clinically Relevant Members of the Fungal Genus Fusarium.Journal of fungi (Basel, Switzerland) · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to investigate the ability of hinokitiol to inhibit the formation of Candida biofilms. Biofilm inhibition was evaluated by quantification of the biofilm metabolic activity with XTT assay. Hinokitiol efficiently prevented biofilm formation in both fluconazole-susceptible and fluconazole-resistant strains of Candida species. We determined the expression levels of specific genes previously implicated in biofilm development of C. albicans cells by real-time RT-PCR. The expression levels of genes associated with adhesion process, HWP1 and ALS3, were downregulated by hinokitiol. Transcript levels of UME6 and HGC1, responsible for long-term hyphal maintenance, were also decreased by hinokitiol. The expression level of CYR1, which encodes the component of signaling pathway of hyphal formation-cAMP-PKA was suppressed by hinokitiol. Its upstream general regulator RAS1 was also suppressed by hinokitiol. These results indicate that hinokitiol may have therapeutic potential in the treatment and prevention of biofilm-associated Candida infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.