Observational studyPloS one2017
Retinal vessel density from optical coherence tomography angiography to differentiate early glaucoma, pre-perimetric glaucoma and normal eyes.
Observational study in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
88 citing papers in PubMed, 1 synthesis or guideline pooled it, 167 citations in OpenAlex.
- Optical Coherence Tomography Evaluation of Peripapillary and Macular Structure Changes in Pre-perimetric Glaucoma, Early Perimetric Glaucoma, and Ocular Hypertension: A Systematic Review and Meta-Analysis.Frontiers in medicine · 2021Pooled it
- Degree of loss in the tissue thickness, microvascular density, specific perimetry and standard perimetry in early glaucoma.BMJ open ophthalmology · 2023Trial
- APSified Peripapillary Vessel Density in Glaucoma Suspects and Open-Angle Glaucoma.Diagnostics (Basel, Switzerland) · 2026Article
- Stress-induced mitochondrial fragmentation in endothelial cells disrupts blood-retinal barrier integrity causing neurodegeneration.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Article
- Comparison of OCT Structural Parameters and OCTA-Measured Retinal Vessel Density and Peripapillary Choroidal Microvasculature in Glaucoma and Optic Neuritis From Multiple Sclerosis or Neuromyelitis Optica.Journal of ophthalmology · 2026Article
- Evaluation of OCT Angiography Parameters as Biomarkers for Glaucoma Progression.Diagnostics (Basel, Switzerland) · 2025Article
- Foveal Avascular Zone Enlargement as a Risk Factor for Early Retinal Ganglion Cell Dysfunction in Glaucoma Suspects.Diagnostics (Basel, Switzerland) · 2025Article
- Optical Coherence Tomography Angiography in Detecting Subclinical Changes in Glaucoma Suspects: A Scoping Review.Cureus · 2025Review
- Comparative evaluation of OCT with OCTA changes at the optic disc and macula in glaucoma suspect and early glaucoma.Indian journal of ophthalmology · 2025Article
- Article
- Evaluating the predictive value of optical coherence tomography angiography metrics and central corneal thickness among glaucoma suspect patients: a comparative cross-sectional study.Medical hypothesis, discovery & innovation ophthalmology journal · 2025Article
- Predicting the impact of retinal vessel density on retinal vessel and tissue oxygenation using a theoretical model.Mathematical biosciences · 2024Article
- Unveiling Novel Structural Biomarkers for the Diagnosis of Glaucoma.Biomedicines · 2024Review
- Glaucoma detection using non-perfused areas in OCTA.Scientific reports · 2024Article
- Detection and agreement of event-based OCT and OCTA analysis for glaucoma progression.Eye (London, England) · 2024Article
- Segmentation of Low-Light Optical Coherence Tomography Angiography Images under the Constraints of Vascular Network Topology.Sensors (Basel, Switzerland) · 2024Article
- Repeatability, interocular correlation and agreement of optic nerve head vessel density in healthy eyes: a swept-source optical coherence tomographic angiography study.International journal of ophthalmology · 2024Article
- Molecular and cellular imaging of the eye.Biomedical optics express · 2024Review
- Sector-Based Regression Strategies to Reduce Refractive Error-Associated Glaucoma Diagnostic Bias When Using OCT and OCT Angiography.Translational vision science & technology · 2023Article
- Repeatability and Comparability of Retinal Blood Vessel Caliber Measurements by OCTA.Vision (Basel, Switzerland) · 2023Article
28 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTo evaluate optic nerve vascular density using swept source optical coherence tomography angiography (OCTA) in patients with early primary open angle glaucoma (POAG), pre-perimetric glaucoma and normal eyes.
methodsThis is a prospective, observational study including 56 eyes in total and divided into 3 groups; 20 eyes with mild POAG, 20 pre-perimetric glaucoma eyes, and 16 age-matched normal eyes as controls. The optic disc region was imaged by a 1050-nm-wavelength swept-source OCT system (DRI OCT Triton, TOPCON). Vessel density was assessed as the ratio of the area occupied by the vessels in 3 distinct regions: 1) within the optic nerve head; 2) in the 3 mm papillary region around the optic disc; and 3) in the peripapillary region, defined as a 700-μm-wide elliptical annulus around the disc. The potential associations between vessel density and structural, functional measures were analyzed.
resultsThere was a statistically significant difference for the peripapillary vessel density, optic nerve head vessel density, and papillary vessel density among all the groups (p<0.001). Control eyes showed a significant difference for all measured vessel densities compared to glaucomatous eyes (p values from 0.001 to 0.024). There was a statistically significant difference between control and pre-perimetric glaucoma eyes for peripapillary, optic nerve head and papillary vessel density values (p values from 0.001 to 0.007). The optic nerve head vessel density, superior and inferior papillary area vessel density (Pearson r = 0.512, 0.436, 0.523 respectively) were highly correlated with mean overall, superior and inferior RNFL thickness in POAG eyes (p = 0.04, p = 0.02 and p = 0.04 respectively). Multiple linear regression analysis of POAG group showed that optic nerve head vessel density in POAG group was more strongly linked to RNFL thickness than to any other variables.
conclusionsEyes with mild POAG could be differentiated from pre-perimetric glaucoma eyes, which also could be differentiated from normal eyes using OCTA-derived retinal vessel density measurements.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.