ArticlePloS one2017
Microsporidia infection impacts the host cell's cycle and reduces host cell apoptosis.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 70 citations in OpenAlex.
- Microsporidia: evolution, infection mechanisms and host impact.Nature reviews. Microbiology · 2026Review
- A microsporidial deubiquitinase blocks ubiquitin transfer from adenylated E1 to human UBE2K ubiquitin conjugating enzyme.bioRxiv : the preprint server for biology · 2025Article
- The Developmental Disorders of Fall Armyworm (Microorganisms · 2025Article
- Distribution of microsporidia in preterm and full-term infant gut microbiomes and implications for host health.Frontiers in pediatrics · 2025Article
- Microsporidian Nosema bombycis secretes serine protease inhibitor to suppress host cell apoptosis via Caspase BmICE.PLoS pathogens · 2025Article
- Influence of Age of Infection on the Gut Microbiota in Worker Honey Bees (Microorganisms · 2024Article
- Article
- Recent Advances in the Biocontrol of Nosemosis in Honey Bees (Journal of fungi (Basel, Switzerland) · 2022Review
- Nosema apis and N. ceranae Infection in Honey bees: A Model for Host-Pathogen Interactions in Insects.Experientia supplementum (2012) · 2022Article
- Transgenerational genomic analyses reveal allelic oscillation and purifying selection in a gut parasiteFrontiers in microbiology · 2022Article
- Fungi of entomopathogenic potential in Chytridiomycota and Blastocladiomycota, and in fungal allies of the Oomycota and Microsporidia.IMA fungus · 2021Review
- A SNP assay for assessing diversity in immune genes in the honey bee (Apis mellifera L.).Scientific reports · 2021Article
- The strength and form of natural selection on transcript abundance in the wild.Molecular ecology · 2021Article
- Potential of Fumagillin andInsects · 2021Article
- Transferrin-mediated iron sequestration suggests a novel therapeutic strategy for controlling Nosema disease in the honey bee, Apis mellifera.PLoS pathogens · 2021Article
- Artificial Diets Modulate Infection Rates byMicroorganisms · 2021Article
- Age and Season Effect the Timing of Adult Worker Honeybee Infection byFrontiers in cellular and infection microbiology · 2021Article
- Innate and Adaptive Immune Responses Against Microsporidia Infection in Mammals.Frontiers in microbiology · 2020Review
- Unexpected encounter of the parasitic kind.World journal of stem cells · 2019Review
- Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intracellular parasites can alter the cellular machinery of host cells to create a safe haven for their survival. In this regard, microsporidia are obligate intracellular fungal parasites with extremely reduced genomes and hence, they are strongly dependent on their host for energy and resources. To date, there are few studies into host cell manipulation by microsporidia, most of which have focused on morphological aspects. The microsporidia Nosema apis and Nosema ceranae are worldwide parasites of honey bees, infecting their ventricular epithelial cells. In this work, quantitative gene expression and histology were studied to investigate how these two parasites manipulate their host's cells at the molecular level. Both these microsporidia provoke infection-induced regulation of genes involved in apoptosis and the cell cycle. The up-regulation of buffy (which encodes a pro-survival protein) and BIRC5 (belonging to the Inhibitor Apoptosis protein family) was observed after infection, shedding light on the pathways that these pathogens use to inhibit host cell apoptosis. Curiously, different routes related to cell cycle were modified after infection by each microsporidia. In the case of N. apis, cyclin B1, dacapo and E2F2 were up-regulated, whereas only cyclin E was up-regulated by N. ceranae, in both cases promoting the G1/S phase transition. This is the first report describing molecular pathways related to parasite-host interactions that are probably intended to ensure the parasite's survival within the cell.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.