ArticlePloS one2017
Comparative analysis of sterol acquisition in the oomycetes Saprolegnia parasitica and Phytophthora infestans.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- Parasitisterols A-C, 24,25-Dihydroxycholestane-Type Triterpenoids, from Oomycete Fish PathogenACS omega · 2026Article
- Loss of Sterol Biosynthesis in Economically Important Plant Pests and Pathogens: A Review of a Potential Target for Pest Control.Biomolecules · 2024Review
- Validation of reference gene stability for normalization of RT-qPCR in Phytophthora capsici Leonian during its interaction with Piper nigrum L.Scientific reports · 2024Article
- Harnessing Plant's Arsenal: Essential Oils as Promising Tools for Sustainable Management of Potato Late Blight Disease Caused byMolecules (Basel, Switzerland) · 2023Review
- The function of plant PR1 and other members of the CAP protein superfamily in plant-pathogen interactions.Molecular plant pathology · 2023Review
- Article
- Functional Analysis of the C-5 Sterol Desaturase PcErg3 in the Sterol Auxotrophic Oomycete PathogenFrontiers in microbiology · 2022Article
- Ecological Dynamics and Microbial Treatments against Oomycete Plant Pathogens.Plants (Basel, Switzerland) · 2021Review
- Identification and Characterization of 24-Dehydrocholesterol Reductase (DHCR24) in the Two-Spotted Cricket,Insects · 2021Article
- Predicting Lifestyle from Positive Selection Data and Genome Properties in Oomycetes.Pathogens (Basel, Switzerland) · 2021Article
- The mysterious route of sterols in oomycetes.PLoS pathogens · 2021Review
- Changes in the Plant β-Sitosterol/Stigmasterol Ratio Caused by the Plant Parasitic NematodePlants (Basel, Switzerland) · 2021Article
- A Cytochrome BFrontiers in plant science · 2021Article
- The Mevalonate Pathway Is Important for Growth, Spore Production, and the Virulence ofFrontiers in microbiology · 2021Article
- Activity and Mechanism of Action of the Bioceramic Silicon Nitride as an Environmentally Friendly Alternative for the Control of the Grapevine Downy Mildew PathogenFrontiers in microbiology · 2020Article
- A High-Quality Grapevine Downy Mildew Genome Assembly Reveals Rapidly Evolving and Lineage-Specific Putative Host Adaptation Genes.Genome biology and evolution · 2019Article
- Genome-wide characterization of Phytophthora infestans metabolism: a systems biology approach.Molecular plant pathology · 2018Article
- Targeting pathogen sterols: Defence and counterdefence?PLoS pathogens · 2017Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The oomycete class includes pathogens of animals and plants which are responsible for some of the most significant global losses in agriculture and aquaculture. There is a need to replace traditional chemical means of controlling oomycete growth with more targeted approaches, and the inhibition of sterol synthesis is one promising area. To better direct these efforts, we have studied sterol acquisition in two model organisms: the sterol-autotrophic Saprolegnia parasitica, and the sterol-heterotrophic Phytophthora infestans. We first present a comprehensive reconstruction of a likely sterol synthesis pathway for S. parasitica, causative agent of the disease saprolegniasis in fish. This pathway shows multiple potential routes of sterol synthesis, and draws on several avenues of new evidence: bioinformatic mining for genes with sterol-related functions, expression analysis of these genes, and analysis of the sterol profiles in mycelium grown in different media. Additionally, we explore the extent to which P. infestans, which causes the late blight in potato, can modify exogenously provided sterols. We consider whether the two very different approaches to sterol acquisition taken by these pathogens represent any specific survival advantages or potential drug targets.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.