ArticlePloS one2017
OxyR-activated expression of Dps is important for Vibrio cholerae oxidative stress resistance and pathogenesis.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
24 citing papers in PubMed, 37 citations in OpenAlex.
- Metagenomic approaches for studying ubiquitous yet diverse nucleoid associated proteins in microbial communities: challenges and advances.World journal of microbiology & biotechnology · 2025Review
- Two redox-responsive LysR-type transcription factors control the oxidative stress response of Agrobacterium tumefaciens.Nucleic acids research · 2025Article
- Environmentally Relevant Concentrations of Tetracycline Promote Horizontal Transfer of Antimicrobial Resistance Genes via Plasmid-Mediated Conjugation.Foods (Basel, Switzerland) · 2024Article
- Understanding the transition to viable but non-culturable state in Escherichia coli W3110: a comprehensive analysis of potential spectrochemical biomarkers.World journal of microbiology & biotechnology · 2024Article
- Intracellular growth of Brucella is mediated by Dps-dependent activation of ferritinophagy.EMBO reports · 2023Article
- Dps-dependent in vivo mutation enhances long-term host adaptation in Vibrio cholerae.PLoS pathogens · 2023Article
- Effects of OxyR regulator on oxidative stress, Apx toxin secretion and virulence ofFrontiers in cellular and infection microbiology · 2023Article
- Intestinal colonization againstAIMS microbiology · 2023Review
- Complementary Roles of Two DNA Protection Proteins fromInternational journal of molecular sciences · 2022Article
- Dps Is a Universally Conserved Dual-Action DNA-Binding and Ferritin Protein.Journal of bacteriology · 2022Review
- Mr.Vc v2: An updated version of database with increased data of transcriptome and experimental validated interactions.Frontiers in microbiology · 2022Article
- OxyR contributes to virulence ofFrontiers in microbiology · 2022Article
- CBS-derived H2S facilitates host colonization of Vibrio cholerae by promoting the iron-dependent catalase activity of KatB.PLoS pathogens · 2021Article
- A multifaceted cellular damage repair and prevention pathway promotes high-level tolerance to β-lactam antibiotics.EMBO reports · 2021Article
- On or Off: Life-Changing Decisions Made byInfectious microbes & diseases · 2020Review
- Pathogenicity and virulence regulation ofVirulence · 2020Review
- Vibrio cholerae Virulence Activator ToxR Regulates Manganese Transport and Resistance to Reactive Oxygen Species.Infection and immunity · 2020Article
- Crosstalks Between Gut Microbiota andFrontiers in cellular and infection microbiology · 2020Review
- Review
- Cyclic di-GMP Increases Catalase Production and Hydrogen Peroxide Tolerance inApplied and environmental microbiology · 2019Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
Vibrio cholerae is the causative agent of cholera, a dehydrating diarrheal disease. This Gram-negative pathogen is able to modulate its gene expression in order to combat stresses encountered in both aquatic and host environments, including stress posed by reactive oxygen species (ROS). In order to further the understanding of V. cholerae's transcriptional response to ROS, we performed an RNA sequencing analysis to determine the transcriptional profile of V. cholerae when exposed to hydrogen hydroperoxide. Of 135 differentially expressed genes, VC0139 was amongst the genes with the largest induction. VC0139 encodes a protein homologous to the DPS (DNA-binding protein from starved cells) protein family, which are widely conserved and are implicated in ROS resistance in other bacteria. Using a promoter reporter assay, we show that during exponential growth, dps is induced by H2O2 in a manner dependent on the ROS-sensing transcriptional regulator, OxyR. Upon entry into stationary phase, the major stationary phase regulator RpoS is required to transcribe dps. Deletion of dps impaired V. cholerae resistance to both inorganic and organic hydroperoxides. Furthermore, we show that Dps is involved in resistance to multiple environmental stresses. Finally, we found that Dps is important for V. cholerae adult mouse colonization, but becomes dispensable in the presence of antioxidants. Taken together, our results suggest that Dps plays vital roles in both V. cholerae stress resistance and pathogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.