ArticleMMWR. Morbidity and mortality weekly report2017
Multiple Fentanyl Overdoses - New Haven, Connecticut, June 23, 2016.
Article in MMWR. Morbidity and mortality weekly report, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it, 98 citations in OpenAlex.
- The Evolving Overdose Epidemic: Synthetic Opioids and Rising Stimulant-Related Harms.Epidemiologic reviews · 2020Pooled it
- Opioid overdoses following use of cocaine and methamphetamine in New South Wales, and the public health responses.Emergency medicine Australasia : EMA · 2025Article
- High-dose naloxone formulations are not as essential as we thought.Harm reduction journal · 2024Review
- CB1 Receptor Negative Allosteric Modulators as a Potential Tool to Reverse Cannabinoid Toxicity.Molecules (Basel, Switzerland) · 2024Article
- Review
- Understanding intentionality of fentanyl use and drug overdose risk: Findings from a mixed methods study of people who inject drugs in New York City.The International journal on drug policy · 2023Article
- Public health and medical preparedness for mass casualties from the deliberate release of synthetic opioids.Frontiers in public health · 2023Article
- Trends in opioid overdose fatalities in Cuyahoga County, Ohio: Multi-drug mixtures, the African-American community and carfentanil.Drug and alcohol dependence reports · 2022Article
- Naloxone's dose-dependent displacement of [Scientific reports · 2022Article
- Synthetic opioids: a review and clinical update.Therapeutic advances in psychopharmacology · 2022Review
- Community overdose surveillance: Comparing substances collected from the death scene investigation to toxicology results.Drug and alcohol dependence · 2021Article
- "I probably got a minute": Perceptions of fentanyl test strip use among people who use stimulants.The International journal on drug policy · 2021Article
- Age-based preferences for risk communication in the fentanyl era: 'A lot of people keep seeing other people die and that's not enough for them'.Addiction (Abingdon, England) · 2021Article
- Methocinnamox Reverses and Prevents Fentanyl-Induced Ventilatory Depression in Rats.The Journal of pharmacology and experimental therapeutics · 2021Article
- Causes, Nature and Toxicology of Fentanyl-Analogues Associated Fatalities: A Systematic Review of Case Reports and Case Series.Journal of pain research · 2021Review
- Therapeutic and Prophylactic Vaccines to Counteract Fentanyl Use Disorders and Toxicity.Journal of medicinal chemistry · 2020Article
- Alcohol or Benzodiazepine Co-involvement With Opioid Overdose Deaths in the United States, 1999-2017.JAMA network open · 2020Article
- The Effects of Intramuscular Naloxone Dose on Mu Receptor Displacement of Carfentanil in Rhesus Monkeys.Molecules (Basel, Switzerland) · 2020Article
- Strengths and weaknesses of existing data sources to support research to address the opioids crisis.Preventive medicine reports · 2020Review
- A latent class analysis of drug and substance use patterns among patients treated in emergency departments for suspected drug overdose.Addictive behaviors · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
On the evening of June 23, 2016, a white powder advertised as cocaine was purchased off the streets from multiple sources and used by an unknown number of persons in New Haven, Connecticut. During a period of less than 8 hours, 12 patients were brought to the emergency department (ED) at Yale New Haven Hospital, experiencing signs and symptoms consistent with opioid overdose. The route of intoxication was not known, but presumed to be insufflation ("snorting") in most cases. Some patients required doses of the opioid antidote naloxone exceeding 4 mg (usual initial dose = 0.1-0.2 mg intravenously), and several patients who were alert after receiving naloxone subsequently developed respiratory failure. Nine patients were admitted to the hospital, including four to the intensive care unit (ICU); three required endotracheal intubation, and one required continuous naloxone infusion. Three patients died. The white powder was determined to be fentanyl, a drug 50 times more potent than heroin, and it included trace amounts of cocaine. The episode triggered rapid notification of public health and law enforcement agencies, interviews of patients and their family members to trace and limit further use or distribution of the fentanyl, immediate naloxone resupply and augmentation for emergency medical services (EMS) crews, public health alerts, and plans to accelerate naloxone distribution to opioid users and their friends and families. Effective communication and timely, coordinated, collaborative actions of community partners reduced the harm caused by this event and prevented potential subsequent episodes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.