Evidence map›Paper›PMID 28151890›Full record

ArticleMedicine2017

Association between depression and enterovirus infection: A nationwide population-based cohort study.

Yin-To Liao, Ming-Hong Hsieh, Yao-Hsu Yang, Ying-Ching Wang, Ching-Shu Tsai, Vincent Chin-Hung Chen, Michael Gossop

Open access · goldAbstract read
In one paragraph

Article in Medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Microbes and Mental Illness: Past, Present, and Future.Healthcare (Basel, Switzerland) · 2023
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. The relationship between vitamin D status and depression in a tactical athlete population.Journal of the International Society of Sports Nutrition · 2019
    Article
  11. Risk of Dementia in Patients with Leptospirosis: A Nationwide Cohort Analysis.International journal of environmental research and public health · 2019
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 2 countries.

Yin-To LiaoDepartment of Psychiatry, Chung Shan Medical University Hospital Department of Psychiatry, School of Medicine, Chung Shan Medical University Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University, Taipei Department of Traditional Chinese Medicine, Chang Gung Memorial Hospital, Puzi City, Chiayi School of Medicine, Fu Jen Catholic University, Taipei Chang Gung Medical Foundation, Chiayi Chang Gung Memorial Hospital Chiayi Chang Gung University, Taoyuan, Taiwan National Addiction Centre, King's College, London, UK.
Ming-Hong Hsieh
Yao-Hsu Yang
Ying-Ching Wang
Ching-Shu Tsai
Vincent Chin-Hung Chen
Michael Gossop
Chiayi Chang Gung Memorial Hospital · TWChang Gung University · TWChung Shan Medical University · TWChung Shan Medical University Hospital · TWFu Jen Catholic University · TWKing's College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Enterovirus (EV) infection is common among children and adolescents. Few studies have investigated the relationship of depression after EV infection. This study explores an association between EV infection and subsequent depression in children and adolescents and assesses the risk of depression after EV infection with central nervous system involvement in a nationwide population-based retrospective cohort.A random sample of 1,000,000 people was derived from Taiwan National Health Insurance Research Database and we identified enrollees less than 18 years with EV infection before 2005 and followed up until December 2009. A total 48,010 cases with EV infection and 48,010 healthy controls matched for sex, age, and residence were obtained. Association between EV infection and depression risk was assessed by Cox proportional hazards models to determine the hazard ratios (HRs) and confidence intervals (CIs). We further stratified EV infection into with central nervous system (CNS) involvement and without and compared with matched cohort.Children and adolescents with EV infection had no elevated risk of depression compared with healthy controls (adjusted HR, aHR = 1.00, 95% CI: 0.83-1.21). However, CNS EV infection was associated with increased risk of depression (aHR = 1.62, 95% CI: 1.02-2.58) in the fully adjusted Cox regression model.To the best of our knowledge, this is the first study investigating depression in children and adolescents with CNS EV infection. The results suggested that children and adolescents with CNS EV infection were a susceptible group for subsequent depressive disorders.

Indexed as

AdolescentCase-Control StudiesCentral Nervous System Viral DiseasesChildChild, PreschoolDepressionDepressive DisorderEnterovirus InfectionsFemaleHumansIncidenceInfantMaleProportional Hazards ModelsRetrospective StudiesRisk Factors

Identifiers

PMID28151890
PMCPMC5293453
OpenAlexW2586815549

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.