← Statins × cardiovascular events

Observational studyMedicine2017

Effect of statin use on clinical outcomes in ischemic stroke patients with atrial fibrillation.

Yi-Ling Wu et al.PubMed ↗Full text ↗Publisher ↗

  • Statin therapylooks good hereNo clear link with recurrent stroke, fewer death during any hospitalization.Correlation only, not a test of it.

What moved togetherboth groups pooled, not the treatment’s effect

Correlation · may be no link

No clear link with recurrent stroke

+1%−12% to +15%

statin therapy vs no statin therapy, in ischemic stroke patients with atrial fibrillation

Smaller than almost all for cardiovascular events

As reported

HR 1.01, 95% CI 0.88–1.15

Correlation, not cause

Statin therapy went with fewer death during any hospitalization

−26%−39% to −11%

statin therapy vs no statin therapy, in ischemic stroke patients with atrial fibrillation

Bigger than 6 in 10 for adverse events & safety

As reported

HR 0.74, 95% CI 0.61–0.89

Who was studied, and how

people with arrhythmia, in this paper

Already taking statin therapy, or nottheir own situation, not assigned

on statin therapy
not on statin therapy

No clear link with recurrent stroke+1%

Statin therapy went with fewer death during any hospitalization−26%

correlation, not a test

the abstract, start to end

… statin therapy (hazard ratios = 1.01, 95% confidence interval 0.88 …

… follow-up period (hazard ratios = 0.74, 95% confidence interval 0.61 …

← favours treatmentfavours comparator →
could be chance
Recurrent strokestatin therapy vs no statin therapy, in ischemic stroke patients with atrial fibrillation
HR 1.010.88–1.15
Death during any hospitalizationstatin therapy vs no statin therapy, in ischemic stroke patients with atrial fibrillation
HR 0.740.61–0.89
StatinsCardiovascular eventsAdverse events & safety
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Full record →Abstract, authors, funding and every citing paper · PMID 28151869