Observational studyRetina (Philadelphia, Pa.)2017
ACUTE POSTERIOR MULTIFOCAL PLACOID PIGMENT EPITHELIOPATHY ON OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY.
Observational study in Retina (Philadelphia, Pa.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The trial behind it
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Who cites it
20 citing papers in PubMed, 64 citations in OpenAlex.
- Article
- Changes in optical coherence tomography (OCT) parameters in follow-up of acute posterior multifocal placoid pigment epitheliopathy (APMPPE).International ophthalmology · 2025Article
- Challenges in posterior uveitis-tips and tricks for the retina specialist.Journal of ophthalmic inflammation and infection · 2023Review
- Acute posterior multifocal placoid pigment epitheliopathy following COVID-19 infection.American journal of ophthalmology case reports · 2023Article
- Changes in Choroidal Thickness and Structure in Preeclampsia with Serous Retinal Detachment.Journal of clinical medicine · 2023Article
- Bilateral acute posterior multifocal placoid pigment epitheliopathy (APMPPE) following SARS-CoV-2 mRNA vaccine.BMJ case reports · 2022Article
- Case Report: Acute Posterior Multifocal Placoid Pigment Epitheliopathy after SARS-CoV-2 Vaccination.Optometry and vision science : official publication of the American Academy of Optometry · 2022Article
- Automated Quantification of Choriocapillaris Lesion Area in Patients With Posterior Uveitis.American journal of ophthalmology · 2021Observational
- Acute posterior multifocal placoid pigment epitheliopathy (APMPPE).Journal of ophthalmic inflammation and infection · 2021Review
- Swept source OCTA reveals a link between choriocapillaris blood flow and vision loss in a case of tubercular serpiginous-like choroiditis.American journal of ophthalmology case reports · 2021Article
- Retinopathy of prematurity and neonatal gut microbiome: An interview with Professor Dimitra Skondra, Associate Professor of Ophthalmology and Vitreoretinal Surgeon at The University of Chicago (USA).Experimental and therapeutic medicine · 2020Article
- Optical coherence tomography angiography in uveitis.Journal of ophthalmic inflammation and infection · 2019Review
- [White dot syndromes : Principles, diagnostics, and treatment].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2019Article
- Hypertensive choroidopathy: Multimodal imaging and the contribution of wide-field swept-source oct-angiography.American journal of ophthalmology case reports · 2019Article
- Acute Posterior Multifocal Placoid Pigment Epitheliopathy Sharing Characteristic OCT Findings of Vogt-Koyanagi-Harada Disease.Case reports in ophthalmological medicine · 2019Article
- Optical Coherence Tomography Angiography in Eyes with Non-infectious Posterior Uveitis; Some Practical Aspects.Medical hypothesis, discovery & innovation ophthalmology journal · 2019Review
- Choroidal perfusion abnormalities associated with Acute Posterior Multifocal Placoid Pigment Epitheliopathy: a case report.BMC ophthalmology · 2018Article
- An overview of the clinical applications of optical coherence tomography angiography.Eye (London, England) · 2018Review
- Choroidal Features of Acute Macular Neuroretinopathy via Optical Coherence Tomography Angiography and Correlation With Serial Multimodal Imaging.JAMA ophthalmology · 2017Article
- Application of OCT-angiography to characterise the evolution of chorioretinal lesions in acute posterior multifocal placoid pigment epitheliopathy.Eye (London, England) · 2017Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
purposeTo investigate choroidal involvement in acute posterior multifocal placoid pigment epitheliopathy (APMPPE).
methodsA retrospective observational case series using multimodal imaging including optical coherence tomography (OCT) angiography.
resultsFive patients with APMPPE were included. In most acute lesions, OCT angiography revealed outer retinal and retinal pigment epithelium (RPE) hyperreflective lesions with attenuated OCT signal in the underlying choroid, but careful examination allowed us to identify a single lesion with decreased choriocapillaris flow outside the signal attenuation. Optical coherence tomography angiography obtained after healing of lesions revealed areas of hypointense circular flow voids clustered in groups surrounded by either isointense or hyperintense signal background. Point-by-point evaluation revealed these flow voids did not correspond to areas of RPE thickening or focal pigmentary changes. Larger hypointense lesions were observed and did correlate with pigmentary changes.
conclusionOur case series demonstrates choriocapillaris flow abnormalities in acute APMPPE extending beyond the OCT lesions, and distinct residual vascular abnormalities in healed APMPPE lesions on OCT angiography. Our findings support a primary ischemic insult to the photoreceptors and RPE, but choriocapillaris flow abnormalities could be secondary to (OCT invisible) retinal and RPE involvement. The lack of understanding of the etiology along with the inability to visualize most of the choroid in acute lesions precludes definite conclusions about the true pathogenesis of APMPPE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.