Evidence map›Paper›PMID 28151799›Full record

ArticleAnnals of surgery2018

Survival, Healthcare Utilization, and End-of-life Care Among Older Adults With Malignancy-associated Bowel Obstruction: Comparative Study of Surgery, Venting Gastrostomy, or Medical Management.

Elizabeth J Lilley, John W Scott, Joel E Goldberg, Christy E Cauley, Jennifer S Temel, Andrew S Epstein, Stuart R Lipsitz, Brittany L Smalls, Adil H Haider, Angela M Bader and 2 more

Open access · greenAbstract readComparative Study
In one paragraph

Article in Annals of surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Gaps in patient-physician communication at the time of malignant bowel obstruction from recurrent gynecologic cancer: a qualitative study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Article
  17. Article
  18. Article
  19. Article
  20. The role of parenteral nutrition in patients with malignant bowel obstruction.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Elizabeth J LilleyCenter for Surgery and Public Health, Brigham and Women's Hospital, Boston, MA.
John W ScottCenter for Surgery and Public Health, Brigham and Women's Hospital, Boston, MA.
Joel E GoldbergDepartment of Surgery, Brigham and Women's Hospital, Boston, MA.
Christy E CauleyAriadne Labs, Boston, MA.
Jennifer S TemelDepartment of Surgery, Massachusetts General Hospital, Boston, MA.
Andrew S EpsteinGastrointestinal Medical Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY.
Stuart R LipsitzCenter for Surgery and Public Health, Brigham and Women's Hospital, Boston, MA.
Brittany L SmallsCenter for Health Services Research, University of Kentucky College of Medicine, Lexington, KY.
Adil H HaiderCenter for Surgery and Public Health, Brigham and Women's Hospital, Boston, MA.
Angela M BaderCenter for Surgery and Public Health, Brigham and Women's Hospital, Boston, MA.
Joel S WeissmanCenter for Surgery and Public Health, Brigham and Women's Hospital, Boston, MA.
Zara CooperCenter for Surgery and Public Health, Brigham and Women's Hospital, Boston, MA.
Brigham and Women's Hospital · USJohnson University · USAriadne Diagnostics (United States) · USMassachusetts General Hospital · USMemorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
CALIFORNIA COORDINATED CANCER PREVENTION & CONTROL PROGRAMU58DP003862 · DP · CALIFORNIA STATE DEPT OF PUBLIC HEALTH · PI SNIPES, KURT P · 2012 to 2014
$31.5M
Program in Cancer Research Outcomes Training (PCORT)R25CA092203 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI GAZELLE, G SCOTT · 2002 to 2016
$8.2M
NCCDPHP CDC HHS U58 DP003862NCI NIH HHS HHSN261201000034CNCI NIH HHS HHSN261201000035CNCI NIH HHS HHSN261201000035INCI NIH HHS HHSN261201000140CNCI NIH HHS P30 CA008748NCI NIH HHS R25 CA092203
6 · The paper itself

Abstract

objectiveTo compare survival, readmissions, and end-of-life care after palliative procedures compared with medical management for malignancy-associated bowel obstruction (MBO).

backgroundMBO is a late complication of intra-abdominal malignancy for which surgeons are frequently consulted. Decisions about palliative treatments, which include medical management, surgery, or venting gastrostomy tube (VGT), are hampered by the paucity of outcomes data relevant to patients approaching the end of life.

methodsRetrospective study using 2001 to 2012 Surveillance, Epidemiology, and End Results-Medicare data of patients 65 years or older with stage IV ovarian or pancreatic cancer who were hospitalized for MBO. Multivariate competing-risks regression models were used to compare the following outcomes: survival, readmission for MBO, hospice enrollment, intensive care unit (ICU) care in the last days of life, and location of death in an acute care hospital.

resultsMedian survival after MBO admission was 76 days (interquartile range 26-319 days). Survival was shorter after VGT [38 days (interquartile range 23-69)] than medical management [72 days (23-312)] or surgery [128 days (42-483)]. As compared to medical management, patients treated with VGT had fewer readmissions [subdistribution hazard ratio 0.41 (0.29-0.58)], increased hospice enrollment [1.65 (1.42-1.91)], and less ICU care [0.69 (0.52-0.93)] and in-hospital death [0.47 (0.36-0.63)]. Surgery was associated with fewer readmissions [0.69 (0.59-0.80)], decreased hospice enrollment [0.84 (0.76-0.92)], and higher likelihood of ICU care [1.38 (1.17-1.64)].

conclusionsVGT is associated with fewer readmissions and lower intensity healthcare utilization at the end of life than do medical management or surgery. Given the limited survival, regardless of management, hospitalization with MBO carries prognostic significance and presents a critical opportunity to identify patients' priorities for end-of-life care.

Indexed as

AgedAged, 80 and overCritical CareFemaleGastrostomyHumansIntestinal ObstructionMaleMedicareOvarian NeoplasmsPalliative CarePancreatic NeoplasmsPatient ReadmissionRetrospective StudiesTerminal CareUnited States

Identifiers

PMID28151799
PMCPMC7509894
OpenAlexW2586900508

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.