ArticleAnnals of surgery2017
Effect of Preoperative Opioid Exposure on Healthcare Utilization and Expenditures Following Elective Abdominal Surgery.
Article in Annals of surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
68 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy of Transversus Abdominis Plane Block in the Reduction of Pain and Opioid Requirement in Laparoscopic and Robot-assisted Hysterectomy: A Systematic Review and Meta-analysis.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2022Pooled it
- A randomized trial of collaborative support for opioid taper after trauma hospitalization.Substance abuse treatment, prevention, and policy · 2024Trial
- Perioperative care for patients with opioid exposure and opioid use disorder: screening and treatment strategies.Current opinion in anaesthesiology · 2026Review
- Article
- Impact of preoperative opioid exposure on cost of care and workplace productivity loss after elective surgery.Regional anesthesia and pain medicine · 2026Article
- Association of patient-reported substance use and postoperative pain.Regional anesthesia and pain medicine · 2026Article
- Impact of Preoperative Opioid Use in Lung Transplant Recipients: A Retrospective Study.Cureus · 2025Article
- Comprehensive Approaches to Pain Management in Postoperative Spinal Surgery Patients: Advanced Strategies and Future Directions.Neurology international · 2025Review
- How Is Preoperative Opioid Use Associated With Readmissions and Outcomes in Lower Extremity Trauma?Clinical orthopaedics and related research · 2025Article
- Assessment of laparotomy-induced stress response in opium- and morphine-addicted rats by measuring serum glucose and corticosterone levels: an animal experiment.Annals of medicine and surgery (2012) · 2025Article
- Impact of opioid-related disorders on complications in patients undergoing bariatric surgery: a propensity score-matched analysis of the national inpatient sample.Surgical endoscopy · 2024Article
- Predictors of postoperative opioid use in ventral and incisional hernia repair.Surgical endoscopy · 2024Article
- Association of substance-use disorder with outcomes of major elective abdominal operations: A contemporary national analysis.Surgery open science · 2024Article
- Perioperative Opioid-Related Harms: Opportunities to Minimize Risk.Seminars in plastic surgery · 2024Review
- Article
- Variation in Intraoperative Opioid Administration by Patient, Clinician, and Hospital Contribution.JAMA network open · 2024Article
- Patient Experiences and Clinical Outcomes in a Multidisciplinary Perioperative Transitional Pain Service.Journal of personalized medicine · 2023Article
- Article
- Prevalence and predictors of long-term opioid use following orthopaedic surgery in an Australian setting: A multicentre, prospective cohort study.Anaesthesia and intensive care · 2023Observational
- INDIVIDUALIZED RISK ASSESSMENT OF PREOPERATIVE OPIOID USE BY INTERPRETABLE NEURAL NETWORK REGRESSION.The annals of applied statistics · 2023Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
objectiveTo examine the extent to which preoperative opioid use is correlated with healthcare utilization and costs following elective surgical procedures. SUMMARY BACKGROUND DATA: Morbidity and mortality associated with prescription opioid use is escalating in the United States. The extent to which chronic opioid use influences postoperative outcomes following elective surgery is not well understood.
methodsTruven Health Marketscan Databases were used to identify adult patients who underwent elective abdominal surgery between June 2009 and December 2012 (n = 200,005). Generalized linear regression was used to determine the effect of preoperative opioid use on postoperative healthcare utilization (length of stay, 30-d readmission, and discharge destination) and cost (hospital stay, 90-, 180-, and 365-d) after adjusting for number of comorbidities, psychological conditions, and demographic characteristics.
resultsIn this cohort, 8.8% of patients used opioids preoperatively. Compared with non-users, patients using opioids preoperatively were more likely to have a longer hospital stay (2.9 d vs. 2.5 d, P <0.001) and were more likely to be discharged to a rehabilitation facility (3.6% vs. 2.5%, P <0.001), adjusting for covariates. Preoperative opioid use was also correlated with a greater rate of 30-day readmission (4.5% vs. 3.6%, P <0.001) and overall greater expenditures at 90- ($12036.60 vs. $3863.40, P <0.001), 180- ($16973.70 vs. $6790.60, P <0.001), and 365- ($25495.70 vs. $12113.80, P <0.001) days following surgery, adjusted for covariates. Additionally, dose-effects were observed regarding readmission, discharge destination, and late healthcare expenditures.
conclusionsPreoperative interventions focused on opioid cessation and alternative analgesics may improve the safety and efficiency of elective surgery among chronic opioid users.
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Registered trials
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