Evidence map›Paper›PMID 28151717›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2017

Synergistic Drug Combinations with a CDK4/6 Inhibitor in T-cell Acute Lymphoblastic Leukemia.

Yana Pikman, Gabriela Alexe, Giovanni Roti, Amy Saur Conway, Andrew Furman, Emily S Lee, Andrew E Place, Sunkyu Kim, Chitra Saran, Rebecca Modiste and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
9.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 106 citations in OpenAlex.

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  12. Pharmacological modulation of RB1 activity mitigates resistance to neoadjuvant chemotherapy in locally advanced rectal cancer.Proceedings of the National Academy of Sciences of the United States of America · 2024
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  17. Estrogen Therapy Induces Receptor-Dependent DNA Damage Enhanced by PARP Inhibition in ER+ Breast Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2023
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Yana PikmanDepartment of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Gabriela AlexeDepartment of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Giovanni RotiDepartment of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Amy Saur ConwayDepartment of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Andrew FurmanDepartment of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Emily S LeeDepartment of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Andrew E PlaceDepartment of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Sunkyu KimNovartis Institutes for BioMedical Research, Inc., Cambridge, Massachusetts.
Chitra SaranNovartis Institutes for BioMedical Research, Inc., Cambridge, Massachusetts.
Rebecca ModisteDepartment of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
David M WeinstockDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Marian HarrisDepartment of Pathology, Boston Children's Hospital, Boston, Massachusetts.
Andrew L KungDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York.
Lewis B SilvermanDepartment of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Kimberly StegmaierDepartment of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts. kimberly_stegmaier@dfci.harvard.edu.
Dana-Farber Cancer Institute · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
The Child Heath Research CenterK12HD052896 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI Wendy K Chung · 2007 to 2026
$7.9M
NCI NIH HHS P30 CA008748NICHD NIH HHS K12 HD052896
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AminopyridinesAnimalsCell Line, TumorCyclin-Dependent Kinase 4DexamethasoneDrug SynergismEverolimusHumansMicePrecursor Cell Lymphoblastic Leukemia-LymphomaPurinesT-LymphocytesTOR Serine-Threonine KinasesXenograft Model Antitumor AssaysAminopyridinesCDK4 protein, humanCyclin-Dependent Kinase 4DexamethasoneEverolimusMTOR protein, humanPurinesribociclibTOR Serine-Threonine Kinases

Identifiers

PMID28151717
PMCPMC5432118
OpenAlexW2566669267

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.