Evidence map›Paper›PMID 28151705›Full record

ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2017

Biomarkers of Tobacco Exposure: Summary of an FDA-Sponsored Public Workshop.

Cindy M Chang, Selvin H Edwards, Aarthi Arab, Arseima Y Del Valle-Pinero, Ling Yang, Dorothy K Hatsukami

Registry-linked trialOpen access · bronzeAbstract readConference Proceedings
In one paragraph

Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04250727 (Switching to a Non-tobacco-based Oral Nicotine Product Among Adult Cigarette Smokers), which is not on this map. Cited by 84 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 2 pooled it
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04250727 nacompletednot on this mapstarted 2021, after this paper: background citation

Switching to a Non-tobacco-based Oral Nicotine Product Among Adult Cigarette Smokers: Exploring the Roles of Product Characteristics and User History

TypeinterventionalSponsorYale UniversityRan2021 to 2022Enrolled30ConditionsTobacco Use Disorder, Oral Nicotine Pouch Use, Smoking Behaviors, Harm ReductionArmsZYN
3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 2 syntheses or guidelines pooled it, 143 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Trial
  7. Five-Day Changes in Biomarkers of Exposure Among Adult Smokers After Completely Switching From Combustible Cigarettes to a Nicotine-Salt Pod System.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020
    Trial
  8. Article
  9. Consistency of Biomarkers of Exposure in the Population Assessment of Tobacco and Health Study from Samples Taken 3 to 5 Years Apart.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026
    Article
  10. Biomarkers of Exposure to Tobacco-Related Toxicants and Oxidative Stress Among Cancer Survivors.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026
    Article
  11. Biomarkers of Exposure to Tobacco-Related Toxicants among Adult Nicotine Pouch Users.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026
    Article
  12. Article
  13. Article
  14. Observational
  15. Article
  16. Article
  17. Article
  18. Research - Investigating Biomarkers Linking Tobacco Use with Cadiovascular Disease Occurrence.jLPHA : the official journal of the Louisiana Public Health Association · 2025
    Article
  19. Article
  20. Biomarkers of Exposure to Nicotine and Selected Toxicants in Individuals Who Use Alternative Tobacco Products Sold in Japan and Canada from 2018 to 2019.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025
    Article

24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Cindy M ChangOffice of Science, Center for Tobacco Products, Food and Drug Administration, Silver Spring, Maryland. Cindy.Chang@fda.hhs.gov.
Selvin H EdwardsOffice of Science, Center for Tobacco Products, Food and Drug Administration, Silver Spring, Maryland.
Aarthi ArabOffice of Science, Center for Tobacco Products, Food and Drug Administration, Silver Spring, Maryland.
Arseima Y Del Valle-PineroOffice of Science, Center for Tobacco Products, Food and Drug Administration, Silver Spring, Maryland.
Ling YangOffice of Science, Center for Tobacco Products, Food and Drug Administration, Silver Spring, Maryland.
Dorothy K HatsukamiDepartment of Psychiatry, Tobacco Research Programs, University of Minnesota, Minneapolis, Minnesota.
United States Food and Drug Administration · USUniversity of Minnesota · US

Funding

Intramural FDA HHS FD999999
6 · The paper itself

Abstract

Since 2009, the FDA Center for Tobacco Products (CTP) has had the authority to regulate the manufacturing, distribution, and marketing of tobacco products in order to reduce the death and disease caused by tobacco use. Biomarkers of exposure pertain to actual human exposure to chemicals arising from tobacco use and could play an important role across a number of FDA regulatory activities, including assessing new and modified-risk tobacco products and identifying and evaluating potential product standards. On August 3-4, 2015, FDA/CTP hosted a public workshop focused on biomarkers of exposure with participants from government, industry, academia, and other organizations. The workshop was divided into four sessions focused on: (i) approaches to evaluating and selecting biomarkers; (ii) biomarkers of exposure and relationship to disease risk; (iii) currently used biomarkers of exposure and biomarkers in development; and (iv) biomarkers of exposure and the assessment of smokeless tobacco and electronic nicotine delivery systems. This article synthesizes the main findings from the workshop and highlights research areas that could further strengthen the science around biomarkers of exposure and help determine their application in tobacco product regulation.

Indexed as

Electronic Nicotine Delivery SystemsBiomarkersCotinineHumansNicotineTobacco, SmokelessTobacco UseUnited StatesUnited States Food and Drug AdministrationBiomarkersCotinineNicotine

Identifiers

PMID28151705
PMCPMC5336443
OpenAlexW2552420678

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.