ArticleJournal of the American Heart Association2017
Left Ventricular Structure and Function in Relation to Environmental Exposure to Lead and Cadmium.
Article in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 65 citations in OpenAlex.
- The environmental exposome in heart failure risk and progression.Nature reviews. Cardiology · 2026Review
- The impact of environmental pollution and climate change on hypertension: a position paper by the European Society of Hypertension (ESH) Working Group on Environment in Hypertension.Cardiovascular research · 2026Review
- Environmental Risk in American Indian Children, Including Cardiovascular and Hematologic Consequences of Cadmium Exposure: Possible Means of Mitigation.International journal of environmental research and public health · 2025Review
- Associations Between Urinary Metal Levels and Incident Heart Failure: A Multi-Cohort Analysis.JACC. Heart failure · 2025Article
- Heavy metal contamination in unrecorded rakia from Kosovo and its public health implications.Scientific reports · 2025Article
- Impact of the environmental pollution on cardiovascular diseases: From epidemiological to molecular evidence.Heliyon · 2024Review
- Cadmium Exposure: Mechanisms and Pathways of Toxicity and Implications for Human Health.Toxics · 2024Review
- The Contribution of Declines in Blood Lead Levels to Reductions in Blood Pressure Levels: Longitudinal Evidence in the Strong Heart Family Study.Journal of the American Heart Association · 2024Article
- Association of urinary bisphenol A levels with heart failure risk in U.S. adults from the NHANES (2003-2016).Frontiers in cardiovascular medicine · 2024Article
- Cadmium exposure induces a sex-dependent decline in left ventricular cardiac function.Life sciences · 2023Article
- Direct Effects of Toxic Divalent Cations on Contractile Proteins with Implications for the Heart: Unraveling Mechanisms of Dysfunction.International journal of molecular sciences · 2023Review
- Public and occupational health risks related to lead exposure updated according to present-day blood lead levels.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Review
- Social and environmental risks as contributors to the clinical course of heart failure.Heart failure reviews · 2022Review
- Changes in the Cardiotoxic Effects of Lead Intoxication in Rats Induced by Muscular Exercise.International journal of molecular sciences · 2022Article
- Urinary Cadmium and Incident Heart Failure: A Case-Cohort Analysis Among Never-Smokers in Denmark.Epidemiology (Cambridge, Mass.) · 2022Article
- Trends in global burden of diseases attributable to lead exposure in 204 countries and territories from 1990 to 2019.Frontiers in public health · 2022Article
- Lead (Pb) exposure and heart failure risk.Environmental science and pollution research international · 2021Review
- Lead and Cadmium as Cardiovascular Risk Factors: The Burden of Proof Has Been Met.Journal of the American Heart Association · 2021Article
- Nutraceutical, Dietary, and Lifestyle Options for Prevention and Treatment of Ventricular Hypertrophy and Heart Failure.International journal of molecular sciences · 2021Review
- A Rare Case of Lead-Induced Cardiomyopathy.JACC. Case reports · 2020Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExperimental studies have demonstrated that lead and cadmium have direct toxic effects on the myocardium, but the few human studies are limited by design, assessment of exposure, and use of heart failure as a late-stage endpoint. METHODS AND
resultsIn a prospective population study, we studied the association of left ventricular (LV) function with blood lead (BPb) and 24-hour urinary cadmium (UCd). In 179 participants randomly recruited from a Flemish population (50.3% women; mean age 39.1 years), geometric mean BPb and UCd at enrollment (1985-2000) were 0.20 μmol/L and 6.1 nmol, respectively. We assessed systolic and diastolic LV function 11.9 years (median) later (2005-2010) by using Doppler imaging of the transmitral blood flow and the mitral annular movement and speckle tracking. In multivariable-adjusted linear regression, LV systolic function decreased with BPb. For a doubling of exposure, estimates were -0.392% for global longitudinal strain (P=0.034), -0.618% and -0.113 s
conclusionsAlthough effect sizes were small, our results suggest that environmental exposure to lead, cadmium, or both might be a risk factor for systolic LV dysfunction, a condition often proceeding to heart failure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.