Evidence map›Paper›PMID 28150939›Full record

ArticleACS chemical neuroscience2017

Antinociceptive Effects of a Novel α2/α3-Subtype Selective GABA

Lakeisha A Lewter, Janet L Fisher, Justin N Siemian, Kashi Reddy Methuku, Michael M Poe, James M Cook, Jun-Xu Li

Abstract read
In one paragraph

Article in ACS chemical neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Antinociceptive Effects ofThe Journal of pharmacology and experimental therapeutics · 2024
    Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Electroacupuncture Suppresses CCI-Induced Neuropathic Pain through GABAA Receptors.Evidence-based complementary and alternative medicine : eCAM · 2022
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. The α2,3-selective potentiator of GABAPharmacology, biochemistry, and behavior · 2019
    Article
  14. Review
  15. Article
  16. The role of loops B and C in determining the potentiation of GABAPharmacology research & perspectives · 2018
    Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lakeisha A LewterDepartment of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo , Buffalo, New York 14214, United States.
Janet L FisherDepartment of Pharmacology, Physiology & Neuroscience, School of Medicine, University of South Carolina , Columbia, South Carolina 29208, United States.
Justin N SiemianDepartment of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo , Buffalo, New York 14214, United States.
Kashi Reddy MethukuDepartment of Chemistry, University of Wisconsin-Milwaukee , Milwaukee, Wisconsin 53211, United States.
Michael M PoeDepartment of Chemistry, University of Wisconsin-Milwaukee , Milwaukee, Wisconsin 53211, United States.
James M CookDepartment of Chemistry, University of Wisconsin-Milwaukee , Milwaukee, Wisconsin 53211, United States.ORCID 0000-0001-5512-3022
Jun-Xu LiDepartment of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo , Buffalo, New York 14214, United States.ORCID 0000-0001-8103-7013

Funding

Development of new drugs for asthma by targeting GABA(A) receptors in the lungR01HL118561 · NHLBI · UNIVERSITY OF WISCONSIN MILWAUKEE · PI COOK, JAMES M · 2014 to 2017
$2.0M
Design of New Therapeutic Agents to Treat SchizophreniaR01MH096463 · NIMH · UNIVERSITY OF WISCONSIN MILWAUKEE · PI COOK, JAMES M · 2013 to 2017
$1.9M
IMIDAZOLINE I2 RECEPTORS AS TARGETS FOR THE TREATMENT OF PAINR01DA034806 · NIDA · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI LI, JUN-XU · 2013 to 2017
$1.7M
Synthesis of Alpha2/Alpha3 GABA Agonists to Treat Neuropathic PainR01NS076517 · NINDS · UNIVERSITY OF WISCONSIN MILWAUKEE · PI COOK, JAMES M · 2012 to 2015
$1.3M
The impact of amygdala CGRP receptors on the development of persistent bladder pain.F32DK128969 · NIDDK · UNIVERSITY OF TEXAS DALLAS · PI LEWTER, LAKEISHA · 2021 to 2023
$210k
NHLBI NIH HHS R01 HL118561NIDA NIH HHS R01 DA034806NIDDK NIH HHS F32 DK128969NIMH NIH HHS R01 MH096463NINDS NIH HHS R01 NS076517
6 · The paper itself

Abstract

Pain remains a challenging clinical condition and spinal GABA

Indexed as

Allosteric RegulationAllosteric SiteAnalgesicsAnimalsGABA-A Receptor AgonistsHEK293 CellsHumansMaleMiceMice, Inbred ICROxazolesReceptors, GABA-AAnalgesicsGABA-A Receptor AgonistsKRM-II-81OxazolesReceptors, GABA-AGABAAmicenestingpainpositive allosteric modulatorwrithing

Identifiers

PMID28150939
PMCPMC5686453

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.