ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2017
Biochemical markers of cartilage metabolism are associated with walking biomechanics 6-months following anterior cruciate ligament reconstruction.
Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
80 citing papers in PubMed, 5 syntheses or guidelines pooled it, 130 citations in OpenAlex.
- Weight-bearing locomotion mitigates the progression of post-traumatic knee osteoarthritis in male rodents: A systematic review and meta-analysis.Osteoarthritis and cartilage · 2026Pooled it
- Differences in gait biomechanics in the first year after anterior cruciate ligament reconstruction: A systematic review.Clinical biomechanics (Bristol, Avon) · 2026Pooled it
- Molecular cartilage pathology following anterior cruciate ligament reconstruction: a systematic review of MRI studies.Frontiers in surgery · 2026Pooled it
- Are Altered Knee Joint Biomechanics Associated with Future Post-Traumatic Osteoarthritis Outcomes? A Systematic Review and Meta-Analysis of Longitudinal Studies.Sports medicine (Auckland, N.Z.) · 2025Pooled it
- Gait-Training Interventions for Individuals With Chronic Ankle Instability: A Systematic Review and Meta-Analysis.Journal of athletic training · 2025Pooled it
- Peak Vertical Ground Reaction Force Modifies Gait Biomechanics Bilaterally Following ACL Reconstruction: A Randomized Experiment.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Trial
- Effect of knee extension constraint training on walking biomechanics 6 months after anterior cruciate ligament reconstruction: a double-blind randomized controlled clinical trial.Journal of orthopaedic surgery and research · 2025Trial
- Modifying loading during gait leads to biochemical changes in serum cartilage oligomeric matrix protein concentrations in a subgroup of individuals with anterior cruciate ligament reconstruction.Clinical rheumatology · 2024Trial
- Immediate Biochemical Changes After Gait Biofeedback in Individuals With Anterior Cruciate Ligament Reconstruction.Journal of athletic training · 2020Trial
- Thigh musculature stiffness during active muscle contraction after anterior cruciate ligament injury.BMC musculoskeletal disorders · 2020Trial
- Gait Mechanics in Women of the ACL-SPORTS Randomized Control Trial: Interlimb Symmetry Improves Over Time Regardless of Treatment Group.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2019Trial
- Sagittal plane walking biomechanics in individuals with knee osteoarthritis after quadriceps strengthening.Osteoarthritis and cartilage · 2019Trial
- Gait mechanics and tibiofemoral loading in men of the ACL-SPORTS randomized control trial.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018Trial
- Association between kinesiophobia and walking gait characteristics in physically active individuals with anterior cruciate ligament reconstruction.Gait & posture · 2018Trial
- Increasing dynamic limb-level loading via real-time biofeedback decreases cumulative loading impulse during gait post-anterior cruciate ligament reconstruction.Clinical biomechanics (Bristol, Avon) · 2026Article
- Acute circulating cartilage-related biomarker responses differ between walking and cycling in healthy young men.European journal of applied physiology · 2026Article
- Walking speed and sound limb loading are related to femoral cartilage thickness but not cartilage deformation in those with traumatic lower-limb amputation.Osteoarthritis and cartilage open · 2026Article
- Early Imaging Biomarkers of Cartilage Strain After ACL Reconstruction Predict Patient Pain and Altered Knee Loading.Annals of biomedical engineering · 2026Article
- Engineered cationic Interleukin-1 receptor antagonist outperforms anakinra at joint retention and preventing IL-1-induced cartilage inflammation.Osteoarthritis and cartilage · 2026Article
- Gait Biomechanical Profiles Following Anterior Cruciate Ligament Reconstruction in Sexually-Immature Pediatrics.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
The purpose of our study was to determine the association between biomechanical outcomes of walking gait (peak vertical ground reaction force [vGRF], vGRF loading rate [vGRF-LR], and knee adduction moment [KAM]) 6 months following anterior cruciate ligament reconstruction (ACLR) and biochemical markers of serum type-II collagen turnover (collagen type-II cleavage product to collagen type-II C-propeptide [C2C:CPII]), plasma degenerative enzymes (matrix metalloproteinase-3 [MMP-3]), and a pro-inflammatory cytokine (interleukin-6 [IL-6]). Biochemical markers were evaluated within the first 2 weeks (6.5 ± 3.8 days) following ACL injury and again 6 months following ACLR in eighteen participants. All peak biomechanical outcomes were extracted from the first 50% of the stance phase of walking gait during a 6-month follow-up exam. Limb symmetry indices (LSI) were used to normalize the biomechanical outcomes in the ACLR limb to that of the contralateral limb (ACLR/contralateral). Bivariate correlations were used to assess associations between biomechanical and biochemical outcomes. Greater plasma MMP-3 concentrations after ACL injury and at the 6-month follow-up exam were associated with lesser KAM LSI. Lesser KAM was associated with greater plasma IL-6 at the 6-month follow-up exam. Similarly, lesser vGRF-LR LSI was associated with greater plasma MMP-3 concentrations at the 6-month follow-up exam. Lesser peak vGRF LSI was associated with higher C2C:CPII after ACL injury, yet this association was not significant after accounting for walking speed. Therefore, lesser biomechanical loading in the ACLR limb, compared to the contralateral limb, 6 months following ACLR may be related to deleterious joint tissue metabolism that could influence future cartilage breakdown. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:2288-2297, 2017.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.