ArticleOrganic & biomolecular chemistry2017
DNA as an environmental sensor: detection and identification of pesticide contaminants in water with fluorescent nucleobases.
Article in Organic & biomolecular chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 21 citations in OpenAlex.
- Immunohistochemical distribution of Bcl-2 and p53 apoptotic markers in acetamiprid-induced nephrotoxicity.Open medicine (Warsaw, Poland) · 2022Article
- A new nickel-based co-crystal complex electrocatalyst amplified by NiO dope Pt nanostructure hybrid; a highly sensitive approach for determination of cysteamine in the presence of serotonin.Scientific reports · 2020Article
- Three new coordination polymers based on bis(4-(4RSC advances · 2019Article
- Recent Advances in Nucleic Acid Targeting Probes and Supramolecular Constructs Based on Pyrene-Modified Oligonucleotides.Molecules (Basel, Switzerland) · 2017Review
- Luminescent Carbon Dot Mimics Assembled on DNA.Journal of the American Chemical Society · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Environmental contaminants pose a substantial health risk in many areas of the world. One of these risks is contamination of water with toxic organic species, such as herbicides and insecticides. Here we describe the discovery and properties of a set of fluorescent chemosensors that respond to micromolar concentrations of a broad range of common organic pesticides. The chemosensors are short DNA-like oligomers with fluorophores replacing DNA bases that are assembled via a DNA synthesizer. We screened a library of 1296 tetrameric compounds on polystyrene microbeads, and identified a set of chemosensor sequences that respond strongly to a set of structurally varied pesticide analytes. We show that ten chemosensors on beads can be used to detect and identify 14 different common pesticides at 100 μM, using the pattern of fluorescence intensity and wavelength changes. Limits of detection for two analytes were as low as 2 μM. The chemosensors are shown to function successfully in a practical setting, correctly identifying unknown pesticide contaminants in water from Felt Lake, California. The results establish a simple, low cost strategy for sensing environmental spills of toxic organics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.