Consider drug efficacy before first-in-human trials.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it.

1. A PRISMA-guided systematic review of pharmacogenetic anticancer clinical trials registered on clinicaltrials.gov.Medicine · 2026
   Pooled it
2. Precision Is Not Enough: When Tools Outpace Translation in Ocular Gene Therapy.Genes · 2026
   Review
3. Assessing risk of bias in toxicological studies in the era of artificial intelligence.Archives of toxicology · 2025
   Review
4. The fundamental role of mitochondria-endoplasmic reticulum contacts in ageing and declining healthspan.Open biology · 2025
   Review
5. Animals in Respiratory Research.International journal of molecular sciences · 2024
   Review
6. Digitalization of toxicology: improving preclinical to clinical translation.Frontiers in toxicology · 2024
   Article
7. Promising strategies in natural products treatments of psoriasis-update.Frontiers in medicine · 2024
   Review
8. Unveiling the fibrotic puzzle of endometriosis: An overlooked concern calling for prompt action.F1000Research · 2024
   Review
9. Era of the 4D animal model.Animal models and experimental medicine · 2023
   Article
10. A New Ethical Framework for Assessing the Unique Challenges of Fetal Therapy Trials.The American journal of bioethics : AJOB · 2022
    Article
11. Individualized therapy trials: navigating patient care, research goals and ethics.Nature medicine · 2021
    Review
12. Do we really know how many clinical trials are conducted ethically? Why research ethics committee review practices need to be strengthened and initial steps we could take to strengthen them.Journal of medical ethics · 2021
    Review
13. Potential of Drug Efficacy Evaluation in Lung and Kidney Cancer Models Using Organ-on-a-Chip Technology.Micromachines · 2021
    Review
14. Moving towards less biased research.BMJ open science · 2021
    Article
15. Open questions for harnessing autophagy-modulating drugs in the SARS-CoV-2 war: hope or hype?Autophagy · 2020
    Article
16. The ethics of innovation for Alzheimer's disease: the risk of overstating evidence for metabolic enhancement protocols.Theoretical medicine and bioethics · 2020
    Article
17. Quantification of clinically applicable stimulation parameters for precision near-organ neuromodulation of human splenic nerves.Communications biology · 2020
    Article
18. Endometriosis: current challenges in modeling a multifactorial disease of unknown etiology.Journal of translational medicine · 2020
    Review
19. Levelling the Translational Gap for Animal to Human Efficacy Data.Animals : an open access journal from MDPI · 2020
    Review
20. Rescuing Informed Consent: How the new "Key Information" and "Reasonable Person" Provisions in the Revised U.S. Common Rule open the door to long Overdue Informed Consent Disclosure Improvements and why we need to walk Through that door.Science and engineering ethics · 2020
    Article

Corrections and comments

• Commented on by
  Preclinical data: Three-point plan for reproducibility.2017

Authors and funding

2 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as