ArticleScientific reports2017
Multimodal optical analysis discriminates freshly extracted human sample of gliomas, metastases and meningiomas from their appropriate controls.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Label-free multiphoton microscopy for intraoperative identification of glioma features and tumor heterogeneity.Frontiers in oncology · 2026Article
- Towards Optical Biopsy in Glioma Surgery.International journal of molecular sciences · 2025Review
- Proof of concept study on differentiating metastatic brain samples by their originating organ using multimodal autofluorescence spectroscopy.Scientific reports · 2025Article
- Multiphoton microscopy imaging of fibrous meningiomas based on the combination of multichannel mode and lambda mode.Frontiers in neuroscience · 2025Article
- Miniature, multi-dichroic instrument for measuring the concentration of multiple fluorophores.Biomedical optics express · 2024Article
- 5-ALA induced PpIX fluorescence spectroscopy in neurosurgery: a review.Frontiers in neuroscience · 2024Review
- Automatic and label-free detection of meningioma in dura mater using the combination of multiphoton microscopy and image analysis.Neurophotonics · 2023Article
- In vivo characterization of the human glioblastoma infiltrative edge with label-free intraoperative fluorescence lifetime imaging.Biomedical optics express · 2023Article
- Intraoperative detection of IDH-mutant glioma using fluorescence lifetime imaging.Journal of biophotonics · 2023Article
- Intraoperative microscopic autofluorescence detection and characterization in brain tumors using stimulated Raman histology and two-photon fluorescence.Frontiers in oncology · 2023Article
- Comparative Study Between a Customized Bimodal Endoscope and a Benchtop Microscope for Quantitative Tissue Diagnosis.Frontiers in oncology · 2022Article
- Characterization of autofluorescence and quantitative protoporphyrin IX biomarkers for optical spectroscopy-guided glioma surgery.Scientific reports · 2021Article
- Molecular changes tracking through multiscale fluorescence microscopy differentiate Meningioma grades and non-tumoral brain tissues.Scientific reports · 2021Article
- Label-free imaging of human brain tissue at subcellular resolution for potential rapid intra-operative assessment of glioma surgery.Theranostics · 2021Article
- Label-Free Macroscopic Fluorescence Lifetime Imaging of Brain Tumors.Frontiers in oncology · 2021Article
- Label-free and noninvasive method for assessing the metabolic status in type 2 diabetic rats with myocardium diastolic dysfunction.Biomedical optics express · 2021Article
- Speckle modulation enables high-resolution wide-field human brain tumor margin detection and in vivo murine neuroimaging.Scientific reports · 2019Article
- Optical Signatures Derived From Deep UV to NIR Excitation Discriminates Healthy Samples From Low and High Grades Glioma.Scientific reports · 2019Article
- Spectral complexity of 5-ALA induced PpIX fluorescence in guided surgery: a clinical study towards the discrimination of healthy tissue and margin boundaries in high and low grade gliomas.Biomedical optics express · 2019Article
- Optical properties, spectral, and lifetime measurements of central nervous system tumors in humans.Scientific reports · 2017Article
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Authors and funding
16 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Delineating tumor margins as accurately as possible is of primordial importance in surgical oncology: extent of resection is associated with survival but respect of healthy surrounding tissue is necessary for preserved quality of life. The real-time analysis of the endogeneous fluorescence signal of brain tissues is a promising tool for defining margins of brain tumors. The present study aims to demonstrate the feasibility of multimodal optical analysis to discriminate fresh samples of gliomas, metastases and meningiomas from their appropriate controls. Tumor samples were studied on an optical fibered endoscope using spectral and fluorescence lifetime analysis and then on a multimodal set-up for acquiring spectral, one and two-photon fluorescence images, second harmonic generation signals and two-photon fluorescence lifetime datasets. The obtained data allowed us to differentiate healthy samples from tumor samples. These results confirmed the possible clinical relevance of this real-time multimodal optical analysis. This technique can be easily applied to neurosurgical procedures for a better delineation of surgical margins.
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