ArticleScientific reports2017
Early life antibiotic exposure affects pancreatic islet development and metabolic regulation.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- In mouse and in vitro models, bowel preparation promotes pathogen colonization, translocation, and exacerbation of inflammation.Cell reports. Medicine · 2026Article
- Article
- The Alteration of Akkermansiaceae/Lachnospiraceae Ratio Is a Microbial Feature of Antibiotic-Induced Microbiota Remodeling.Bioinformatics and biology insights · 2023Article
- Maternal Mycobiome, but Not Antibiotics, Alters Fungal Community Structure in Neonatal Piglets.Applied and environmental microbiology · 2022Article
- Maintenance of gut microbiome stability for optimum intestinal health in pigs - a review.Journal of animal science and biotechnology · 2022Review
- The Role of Gut Microbiota in the Skeletal Muscle Development and Fat Deposition in Pigs.Antibiotics (Basel, Switzerland) · 2022Article
- Neonatal Programming of Microbiota Composition: A Plausible Idea That Is Not Supported by the Evidence.Frontiers in microbiology · 2022Review
- Maternal antibiotic treatment affects offspring gastric sensing for umami taste and ghrelin regulation in the pig.Journal of animal science and biotechnology · 2021Article
- Skin and metabolic syndrome: A review of the possible associations.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2021Review
- Vancomycin-Induced Modulation of Gram-Positive Gut Bacteria and Metabolites Remediates Insulin Resistance in iNOS Knockout Mice.Frontiers in cellular and infection microbiology · 2021Article
- Review
- Antibiotic treatment triggers gut dysbiosis and modulates metabolism in a chicken model of gastro-intestinal infection.BMC veterinary research · 2019Article
- Neonatal Exposure to Amoxicillin Alters Long-Term Immune Response Despite Transient Effects on Gut-Microbiota in Piglets.Frontiers in immunology · 2019Article
- Selectived and Reshaped Early Dominant Microbial Community in the Cecum With Similar Proportions and Better Homogenization and Species Diversity Due to Organic Acids as AGP Alternatives Mediate Their Effects on Broilers Growth.Frontiers in microbiology · 2019Article
- "Gut Microbiota-Circadian Clock Axis" in Deciphering the Mechanism Linking Early-Life Nutritional Environment and Abnormal Glucose Metabolism.International journal of endocrinology · 2019Review
- Antimicrobial Effects on Swine Gastrointestinal Microbiota and Their Accompanying Antibiotic Resistome.Frontiers in microbiology · 2019Review
- Establishing a model for childhood obesity in adolescent pigs.Obesity science & practice · 2018Article
- Patterns of Early-Life Gut Microbial Colonization during Human Immune Development: An Ecological Perspective.Frontiers in immunology · 2017Review
- Long-term effects of early antibiotic intervention on blood parameters, apparent nutrient digestibility, and fecal microbial fermentation profile in pigs with different dietary protein levels.Journal of animal science and biotechnology · 2017Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
Childhood antibiotic exposure has been recently linked with increased risk of metabolic disease later in life. A better understanding of this association would potentially provide strategies to reduce the childhood chronic disease epidemic. Therefore, we explored the underlying mechanisms using a swine model that better mimics human infants than rodents, and demonstrated that early life antibiotic exposure affects glucose metabolism 5 weeks after antibiotic withdrawal, which was associated with changes in pancreatic development. Antibiotics exerted a transient impact on postnatal gut microbiota colonization and microbial metabolite production, yet changes in the expression of key genes involved in short-chain fatty acid signaling and pancreatic development were detected in later life. These findings suggest a programming effect of early life antibiotic exposure that merits further investigation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.