ArticlePsychophysiology2017
Association between neural reactivity and startle reactivity to uncertain threat in two independent samples.
Article in Psychophysiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Acute orexin antagonism selectively modulates anticipatory anxiety in humans: implications for addiction and anxiety.Translational psychiatry · 2022Trial
- Severe PTSD symptoms magnify episodic memory-encoding deficits and amygdala-ACC attenuation during unpredictable threat in male combat veterans.Molecular psychiatry · 2026Article
- Neuropsychology of Generalized Anxiety Disorder in Clinical Setting: A Systematic Evaluation.Healthcare (Basel, Switzerland) · 2023Review
- Behavioral and brain reactivity to uncertain stress prospectively predicts binge drinking in youth.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Startle during threat longitudinally predicts functional impairment independent of DSM diagnoses.Psychiatry research · 2019Article
- Neural correlates of predictable and unpredictable threat in internalizing psychopathology.Neuroscience letters · 2019Article
- The Electrical Aftermath: Brain Signals of Posttraumatic Stress Disorder Filtered Through a Clinical Lens.Frontiers in psychiatry · 2019Article
- Association among anterior cingulate cortex volume, psychophysiological response, and PTSD diagnosis in a Veteran sample.Neurobiology of learning and memory · 2018Article
- The Affective and Neural Correlates of Heroin versus Cocaine Use in Addiction Are Influenced by Environmental Setting But in Opposite Directions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- The Future of Contextual Fear Learning for PTSD Research: A Methodological Review of Neuroimaging Studies.Current topics in behavioral neurosciencesReview
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Prior studies indicate that anxiety disorders are associated with heightened sensitivity to uncertain threat (U threat). Individual differences in reactivity to U threat have been measured in the laboratory with two methodologies-startle eyeblink potentiation and fMRI. While startle and fMRI are purported to relate to each other, very little research exists on whether individual differences in one measure are associated with individual differences in another and, thus, whether startle and fMRI capture shared mechanisms. Therefore, the current study was designed to investigate if and where in the brain measures of startle potentiation and fMRI BOLD signal correlate during response to U threat across two independent samples. Participants in both studies completed two threat anticipation tasks-once during collection of startle potentiation and once during fMRI. In Study 1 (n = 43), the startle and fMRI tasks both used electric shock as the threat. As an extension, in Study 2 (n = 38), the startle task used electric shock but the fMRI task used aversive images. Despite these methodological differences, greater startle potentiation to U threat was associated with greater dorsal anterior cingulate, caudate, and orbitofrontal cortex reactivity to U threat in both samples. The findings suggest that startle and fMRI measures of responding to U threat overlap, and points toward an integrated brain-behavior profile of aberrant U threat responding.
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Registered trials
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