ArticleClinical neuroradiology2018
Growth of Untreated Unruptured Small-sized Aneurysms (≺7mm): Incidence and Related Factors.
Article in Clinical neuroradiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Meta-Analysis of Rupture Risk for Intracranial Aneurysms 10 mm or Less in Size Selected for Conservative Management Without Repair.Frontiers in neurology · 2021Pooled it
- Super-resolution deep learning reconstruction enhances visualization of cerebral aneurysms on magnetic resonance angiography.Neuroradiology · 2026Article
- Magnetic resonance imaging finding of coexistence of bilateral paraclinoid aneurysms in a patient with a nonfunctioning macroadenoma, simultaneous resection, and clipping: illustrative case.Journal of neurosurgery. Case lessons · 2022Article
- Risk factors for the progression of unruptured intracranial aneurysms in patients followed by CT/MR angiography.Quantitative imaging in medicine and surgery · 2021Article
- Knowledge framework and emerging trends in intracranial aneurysm magnetic resonance angiography: a scientometric analysis from 2004 to 2020.Quantitative imaging in medicine and surgery · 2021Article
- Performance of a Deep-Learning Neural Network to Detect Intracranial Aneurysms from 3D TOF-MRA Compared to Human Readers.Clinical neuroradiology · 2020Article
- Growth of Asymptomatic Intracranial Fusiform Aneurysms : Incidence and Risk Factors.Clinical neuroradiology · 2019Article
- Letter to the Editor Regarding "Growth of Untreated Unruptured Small-sized Aneurysms (<7 mm): Incidence and Related Factors".Clinical neuroradiology · 2018Article
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11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe need to treat small (<7 mm) unruptured aneurysms is still controversial, despite data collected through several large cohort studies. Such lesions typically are incidental findings, usually followed for potential growth through serial imaging. For this study, growth estimates for untreated unruptured small-sized aneurysms were generated, examining incidence and related risk factors.
methodsA cohort of 135 consecutive patients harboring 173 untreated unruptured small-sized aneurysms (<7 mm) was subjected to extended monitoring (mean, 73.1 ± 30.0 months). Growth was defined as a 1-mm increase at minimum in one or more aneurysmal dimensions or as a significant change in shape. Medical records and radiological data were reviewed. Cumulative growth rate and related risk factors were analyzed via Cox proportional hazards regression and Kaplan-Meier product-limit estimator.
resultsA total of 28 aneurysms (16.2%) displayed growth during continued surveillance (1054.1 aneurysm-years). The annual growth rate was 2.65% per aneurysm-year, with 15 surfacing within 60 months and 13 after 60 months. Multivariate analysis indicated that bifurcation type was the sole significant risk factor (hazard ratio HR = 7.64; p < 0.001) in terms of growth. Cumulative survival rates without growth were significantly lower in subjects with bifurcation aneurysms than with side-wall aneurysms (p < 0.001). During the follow-up period, one patient suffered a subarachnoid hemorrhage and then aneurysm growth was detected.
conclusionMost (83.8%) untreated unruptured small-sized aneurysms (<7 mm) remained stable and devoid of growth in long-term follow-up. Because bifurcation aneurysms were prone to eventual growth, careful long-term monitoring at regular intervals is advised if left untreated.
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