Evidence map›Paper›PMID 28150062›Full record

ArticlePrevention science : the official journal of the Society for Prevention Research2018

Transactions Between Substance Use Intervention, the Oxytocin Receptor (OXTR) Gene, and Peer Substance Use Predicting Youth Alcohol Use.

H Harrington Cleveland, Amanda M Griffin, Pedro S A Wolf, Richard P Wiebe, Gabriel L Schlomer, Mark E Feinberg, Mark T Greenberg, Richard L Spoth, Cleve Redmond, David J Vandenbergh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Prevention science : the official journal of the Society for Prevention Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Alcohol and oxytocin: Scrutinizing the relationship.Neuroscience and biobehavioral reviews · 2021
    Review
  4. Article
  5. Review
  6. Article
  7. The Implications of Genetics for Prevention and Intervention Programming.Prevention science : the official journal of the Society for Prevention Research · 2018
    Article
  8. Commentary for Special Issue of Prevention Science "Using Genetics in Prevention: Science Fiction or Science Fact?"Prevention science : the official journal of the Society for Prevention Research · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

H Harrington ClevelandDepartment of Human Development and Family Studies, Penn State, 119 Health and Human Development, University Park, PA, USA. hhc10@psu.edu.
Amanda M GriffinDepartment of Human Development and Family Studies, Penn State, 119 Health and Human Development, University Park, PA, USA.
Pedro S A WolfDepartment of Human Development and Family Studies, Penn State, 119 Health and Human Development, University Park, PA, USA.
Richard P WiebeBehavioral Sciences, Fitchburg State University, Fitchburg, MA, USA.
Gabriel L SchlomerEducational Psychology and Methodology, University at Albany, State University of New York, 1400 Washington Ave, Albany, NY, USA.
Mark E FeinbergBennett Pierce Prevention Research Center, Penn State, 316 Biobehavioral Health, University Park, PA, USA.
Mark T GreenbergDepartment of Human Development and Family Studies, Penn State, 119 Health and Human Development, University Park, PA, USA.
Richard L SpothPartnerships in Prevention Science Institute, Iowa University, 2625 N. Loop Drive, Suite 2400, Ames, IA, USA.
Cleve RedmondPartnerships in Prevention Science Institute, Iowa University, 2625 N. Loop Drive, Suite 2400, Ames, IA, USA.
David J VandenberghDepartment of Biobehavioral Health, Penn State, 258A Health and Human Development, University Park, PA, USA.
Pennsylvania State University · USPrevention Institute · USFitchburg State University · USUniversity at Albany, State University of New York · US

Funding

Partnership Model for Diffusion of Proven PreventionR01DA013709 · NIDA · IOWA STATE UNIVERSITY · PI SPOTH, RICHARD · 2002 to 2017
$35.0M
PREVENTION AND METHODOLOGY TRAINING (PAMT)T32DA017629 · NIDA · PENNSYLVANIA STATE UNIVERSITY-UNIV PARK · PI Eric D Claus, Rina D Eiden · 2005 to 2026
$9.5M
Friendship Networks and Emergence of Substance UseR01DA018225 · NIDA · PENNSYLVANIA STATE UNIVERSITY, THE · PI FEINBERG, MARK ETHAN · 2007 to 2017
$2.9M
Implications of Genetic Variance for Substance Use Interventions in AdolescenceR01DA030389 · NIDA · PENNSYLVANIA STATE UNIVERSITY, THE · PI CLEVELAND, HOBART HARRINGTON, VANDENBERGH, DAVID J · 2011 to 2014
$2.2M
NIDA NIH HHS R01 DA013709NIDA NIH HHS R01 DA018225NIDA NIH HHS R01 DA030389NIDA NIH HHS T32 DA017629
6 · The paper itself

Abstract

This study investigated the oxytocin receptor (OXTR) gene's moderation of associations between exposure to a substance misuse intervention, average peer substance use, and adolescents' own alcohol use during the 9th-grade. OXTR genetic risk was measured using five single nucleotide polymorphisms (SNPs), and peer substance use was based on youths' nominated closest friends' own reports of alcohol, cigarette, and marijuana use, based on data from the PROSPER project. Regression models revealed several findings. First, low OXTR risk was linked to affiliating with friends who reported less substance use in the intervention condition but not the control condition. Second, affiliating with high substance-using friends predicted youth alcohol risk regardless of OXTR risk or intervention condition. Third, although high OXTR risk youth in the intervention condition who associated with low substance-using friends reported somewhat higher alcohol use than comparable youth in the control group, the absolute level of alcohol use among these youth was still among the lowest in the sample.

Indexed as

Peer GroupAdolescentChildGenetic VariationHumansPolymorphism, Single NucleotideReceptors, OxytocinRisk AssessmentUnderage DrinkingOXTR protein, humanReceptors, OxytocinAlcohol researchGene x intervention researchInterventionOxytocin receptor gene

Identifiers

PMID28150062
PMCPMC5696096
OpenAlexW2586028521

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.