Observational studyGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2017
Choroidal structures in polypoidal choroidal vasculopathy, neovascular age-related maculopathy, and healthy eyes determined by binarization of swept source optical coherence tomographic images.
Observational study in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05278169 (Central Serous Chorioretinopathy Registry and Pachychoroid Observation and Natural History Study), which is not on this map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Central Serous Chorioretinopathy Registry and Pachychoroid Observation and Natural History Study
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Choroidal vascularity index is independent of ocular and image-based factors in healthy eyes: a systematic review and meta-analysis.Scientific reports · 2025Pooled it
- Choroidal binarization analysis: clinical application.International ophthalmology · 2019Pooled it
- Impact of Optical Coherence Tomography Scan Pattern and Chorio-Scleral Interface Delineation on Choroidal Vascularity Index Measurements.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Article
- OCT and OCTA quantitative metrics for polypoidal choroidal vasculopathy.BMJ open ophthalmology · 2025Review
- Inter-Relationships Between the Deep Learning-Based Pachychoroid Index and Clinical Features Associated with Neovascular Age-Related Macular Degeneration.Journal of clinical medicine · 2025Article
- Evaluation of choroidal thickness and choroidal vascularity index in patients with Crimean-Congo hemorrhagic fever.International ophthalmology · 2023Article
- Changes in choroidal tissue post-supplementation with vitamin D in pediatric patients who are deficient in vitamin D.International ophthalmology · 2023Article
- Recent Advances in Imaging Polypoidal Choroidal Vasculopathy with Swept-Source Optical Coherence Tomography Angiography.Diagnostics (Basel, Switzerland) · 2023Review
- A Comparative Study of Choroidal Vascular and Structural Characteristics of Typical Polypoidal Choroidal Vasculopathy and Polypoidal Choroidal Neovascularization: OCTA-Based Evaluation of Intervortex Venous Anastomosis.Diagnostics (Basel, Switzerland) · 2022Article
- Influence of scan direction on subfoveal choroidal vascularity index using optical coherence tomography.Scientific reports · 2022Article
- Three-dimensional modelling of the choroidal angioarchitecture in a multi-ethnic Asian population.Scientific reports · 2022Article
- Comparison of choroidal hyperreflective spots on optical coherence tomography images between both eyes of normal subjects.Quantitative imaging in medicine and surgery · 2022Article
- Imaging Characteristics of Neovascular and Atrophic Pachychoroidal Spectrum Diseases.Frontiers in medicine · 2022Article
- Article
- Recurrence and visual prognostic factors of polypoidal choroidal vasculopathy: 5-year results.Scientific reports · 2021Article
- The effect of phacoemulsification performed with vitrectomy on choroidal vascularity index in eyes with vitreomacular diseases.Scientific reports · 2021Article
- A comparative study on the choroidal vascularity index and the determination of cut-off values in the pachychoroid spectrum diseases.Japanese journal of ophthalmology · 2021Article
- Peripapillary Choroidal Vascularity Outside the Macula in Patients With Central Serous Chorioretinopathy.Translational vision science & technology · 2021Article
- Associations Between the Choroidal Vascularity Index and Malignant Glaucoma After Trabeculectomy for Primary Angle Closure Glaucoma.Frontiers in medicine · 2021Article
- Choroidal vascular changes in age-related macular degeneration: A protocol for systematic review and meta-analysis.Medicine · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate quantitatively the choroidal vascularity in polypoidal choroidal vasculopathy (PCV) and neovascular age-related macular degeneration (AMD) patients compared to healthy controls.
methodsAll eyes underwent swept source optical coherence tomography (OCT), and choroidal images were binarized into blood vessels lumen and stroma. The choroidal vascular index (CVI) was defined as the ratio of luminal area (LA) over total choroidal area of the subfoveal region with a width of 1500 μm.
resultsThe study included 73 patients with neovascular AMD or PCV with mean ± standard deviation (SD) age of 71.8 ± 9.3 years, which was older than the mean age of 65.1 ± 10.8 years of 72 healthy eyes from control group (p < 0.01). The 44 PCV eyes had significantly higher mean SFCT of 214.23 ± 95.21 μm than neovascular AMD eyes (172.74 ± 96.48 μm, p = 0.03) and greater luminal area (0.23 ± 0.09 mm
conclusionDespite physiological changes of choroidal vasculature due to aging, the choroidal morphology is different in PCV, neovascular AMD and healthy eyes, which has implication on disease pathogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.