ReviewJournal of animal science and biotechnology2017
The development and role of microbial-host interactions in gut mucosal immune development.
Review in Journal of animal science and biotechnology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed.
- Porcine epidemic diarrhea virus infection promotes Peyer's patch immune induction and epithelial defense via single-cell transcriptional reprogramming.Microbiology spectrum · 2026Article
- Gut Microbiota-Mucosal Immune Interactions Underlying Intestinal Homeostasis in Weaned Piglets.Animals : an open access journal from MDPI · 2026Review
- A multi-omics characterization of the gut microbiota of weaned piglets in response toJournal of animal science and technology · 2026Article
- Multi-omics profiling of sow colostrum and faecal microbiota reveals parity-dependent and independent factors associated with piglet survival and growth.Journal of animal science and biotechnology · 2026Article
- Multi-omics integrated approach reveals host-microbiome interactions in the adaptive mechanisms of weaning piglets.Journal of animal science and technology · 2026Article
- Review
- Gut morphology and blood biochemical parameters of growing pigs fed diets with a partial to total replacement of soybean meal withFrontiers in veterinary science · 2026Article
- Empowering large litters: can enhanced pen design with simulated udders improve piglet growth in their early life?Translational animal science · 2026Article
- PEDV Structural Proteins with Emphasis on M Protein as an Immunomodulatory Factor in Porcine Innate Immunity.Life (Basel, Switzerland) · 2025Review
- Early antimicrobial regimen shapes gut microbiota and health trajectories in pigs: a longitudinal study from weaning to finishing.Animal microbiome · 2025Article
- Pinto Bean Supplementation Modulates Gut Microbiota and Improves Markers of Gut Integrity in a Mouse Model of Estrogen Deficiency.The Journal of nutrition · 2025Article
- DietaryVeterinary sciences · 2025Article
- Bacterial profiles of the oral, vaginal, and rectal mucosa and colostrum of periparturient sows.PloS one · 2025Article
- Modeling the weaning diet of piglets with fermented feed material: effects on growth performance and health parameters.Frontiers in veterinary science · 2025Article
- Temporal dynamics in the composition of metabolically active bacteria and fungi in the ileo-cecal lymph nodes of suckling and newly weaned piglets.Scientific reports · 2024Article
- Effects of electrolyte balance on intestinal barrier, amino acid metabolism, and mTORC1 signaling pathway in piglets fed low-protein diets.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2024Article
- Aspirin eugenol ester affects ileal barrier function, inflammatory response and microbiota in broilers under lipopolysaccharide-induced immune stress conditions.Frontiers in veterinary science · 2024Article
- Impact of Early Weaning on Development of the Swine Gut Microbiome.Microorganisms · 2023Review
- A Comparative Analysis of the Fecal Bacterial Communities of Light and Heavy Finishing Barrows Raised in a Commercial Swine Production Environment.Pathogens (Basel, Switzerland) · 2023Article
- Gut Health and Influencing Factors in Pigs.Animals : an open access journal from MDPI · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
At birth the piglet's immune system is immature and it is dependent upon passive maternal protection until weaning. The piglet's mucosal immune system develops over the first few weeks but has not reached maturity at weaning ages which are common on commercial farms. At weaning piglets are presented with a vast and diverse range of microbial and dietary/environmental antigens. Their ability to distinguish between antigens and mount a protective response to potential pathogens and to develop tolerance to dietary antigens is critical to their survival and failure to do so is reflected in the high incidence of morbidity and mortality in the post-weaning period. A growing recognition that the widespread use of antibiotics to control infection during this critical period should be controlled has led to detailed studies of those factors which drive the development of the mucosal immune system, the role of gut microbiota in driving this process, the origin of the bacteria that colonise the young piglet's intestine and the impact of rearing environment. This review briefly describes how the mucosal immune system is equipped to respond "appropriately" to antigenic challenge and the programmed sequence by which it develops. The results of studies on the critical interplay between the host immune system and gut microbiota are discussed along with the effects of rearing environment. By comparing these with results from human studies on the development of allergies in children, an approach to promote an earlier maturation of the piglet immune system to resist the challenges of weaning are outlined.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.