ArticleBiology of sex differences2017
Bariatric surgery emphasizes biological sex differences in rodent hepatic lipid handling.
Article in Biology of sex differences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Review: Sex-Specific Aspects in the Bariatric Treatment of Severely Obese Women.International journal of environmental research and public health · 2020Pooled it
- DENND5B disruption results in reduced body fat and increased intestinal fatty acid oxidation by activation of autophagy.Journal of lipid research · 2026Article
- Dynamic Lipidomic Remodeling and Clinical Correlations after Sleeve Gastrectomy in Obese Subjects.Diabetes & metabolism journal · 2026Article
- Glucose metabolism after bariatric surgery: implications for T2DM remission and hypoglycaemia.Nature reviews. Endocrinology · 2023Review
- The role of obesity and bariatric surgery-induced weight loss in breast cancer.Cancer metastasis reviews · 2022Review
- Sex-specific differences in metabolic outcomes after sleeve gastrectomy and intermittent fasting in obese middle-aged mice.American journal of physiology. Endocrinology and metabolism · 2022Article
- Diet-dependent sex differences in the response to vertical sleeve gastrectomy.American journal of physiology. Endocrinology and metabolism · 2021Article
- Intestinal extracellular vesicles are altered by vertical sleeve gastrectomy.American journal of physiology. Gastrointestinal and liver physiology · 2021Article
- Dysregulated appetitive leptin signaling in male rodent offspring from post-bariatric dams.Current research in physiology · 2020Article
- Curbing Obesity from One Generation to Another: the Effects of Bariatric Surgery on the In Utero Environment and Beyond.Reproductive sciences (Thousand Oaks, Calif.) · 2020Review
- Oea Signaling Pathways and the Metabolic Benefits of Vertical Sleeve Gastrectomy.Annals of surgery · 2020Article
- Nutrient and hormone composition of milk is altered in rodent dams post-bariatric surgery.Journal of developmental origins of health and disease · 2020Article
- Sex-Specific Glucose Homeostasis and Anthropometric Responses to Sleeve Gastrectomy in Obese Patients.Nutrients · 2019Article
- Inflammatory responses to dietary and surgical weight loss in male and female mice.Biology of sex differences · 2019Article
- Refinement of Perioperative Feeding in a Mouse Model of Vertical Sleeve Gastrectomy.Journal of the American Association for Laboratory Animal Science : JAALAS · 2018Article
- Vertical sleeve gastrectomy corrects metabolic perturbations in a low-exercise capacity rat model.Molecular metabolism · 2018Article
- Anxiety behavior and hypothalamic-pituitary-adrenal axis altered in a female rat model of vertical sleeve gastrectomy.PloS one · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundEighty percent of patients who receive bariatric surgery are women, yet the majority of preclinical studies are in male rodents. Because sex differences drive hepatic gene expression and overall lipid metabolism, we sought to determine whether sex differences were also apparent in these endpoints in response to bariatric surgery.
methodsTwo cohorts of age-matched virgin male and female Long-Evans rats were placed on a high fat diet for 3 weeks and then received either Sham or vertical sleeve gastrectomy (VSG), a surgery which resects 80% of the stomach with no intestinal rearrangement.
resultsEach sex exhibited significantly decreased body weight due to a reduction in fat mass relative to Sham controls (
conclusionsTaken together, although both males and females lose weight and improve plasma lipids, there are large-scale sex differences in hepatic gene expression and consequently hepatic lipid metabolism after VSG.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.