Evidence map›Paper›PMID 28149479›Full record

ReviewJournal of clinical and experimental dentistry2017

Prophylaxis and antibiotic therapy in management protocols of patients treated with oral and intravenous bisphosphonates.

Elena-Beatriz Bermúdez-Bejarano, María-Ángeles Serrera-Figallo, Aida Gutiérrez-Corrales, Manuel-María Romero-Ruiz, Raquel Castillo-de-Oyagüe, José-Luis Gutiérrez-Pérez, Daniel Torres-Lagares

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PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of clinical and experimental dentistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.

  1. Guideline
  2. Interventions for managing medication-related osteonecrosis of the jaw.The Cochrane database of systematic reviews · 2017
    Pooled it
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Mechanism, prevention, and treatment for medication-related osteonecrosis of the jaws.Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2021
    Review
  17. Article
  18. Article
  19. Review
  20. Treatment of Stage 2 Medication-Induced Osteonecrosis of the Jaw: A Case Series.International journal of environmental research and public health · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Elena-Beatriz Bermúdez-BejaranoMaster's Degree in Oral Surgery. School of Dentistry. University of Seville.
María-Ángeles Serrera-FigalloAssociate Professor. Integrated Dentistry and Patients with Special Diseases. School of Dentistry. University of Seville.
Aida Gutiérrez-CorralesMaster's Degree in Oral Surgery. School of Dentistry. University of Seville.
Manuel-María Romero-RuizMaster's Degree in Oral Surgery. School of Dentistry. University of Seville.
Raquel Castillo-de-OyagüeProfessor of Prostheses. Department of Stomatology. School of Dentistry. Complutense University of Madrid.
José-Luis Gutiérrez-PérezProfessor of Oral Surgery. School of Dentistry. University of Seville.
Daniel Torres-LagaresProfessor of Oral Surgery. School of Dentistry. University of Seville.
Universidad de Sevilla · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionOsteonecrosis of the jaw (MRONJ) linked to bisphosphonate treatment has specific characteristics that render its therapeutic management challenging for clinicians. Poor response to standard treatment makes it essential to take special precautions when treating this type of disease; therefore, antibiotic prophylaxis and/or antibiotic therapy have been proposed as effective and helpful tools in these situations.

objectivesThis article seeks to assess published evidence in order to evaluate the different protocols used for antibiotic prophylaxis and/or antibiotic therapy in the general context of patients treated with bisphosphonates. MATERIAL AND

methodsA literature review of the last 10 years was carried out in PubMed using the following keywords: "antibiotic prophylaxis and osteonecrosis," "bisphosphonates AND osteonecrosis AND dental management," "bisphosphonate AND osteonecrosis AND antibiotic prophylaxis AND oral surgery." A total of 188 articles were obtained, of which 18 were ultimately selected. RESULTS AND DISCUSSION: In patients treated with oral and intravenous bisphosphonates without chemotherapy-associated osteonecrosis of the jaw, antibiotic prophylaxis prior to oral surgery is an important tool to avoid osteonecrosis and promote healing of the affected area. If the patient previously exhibited chemotherapy-associated osteonecrosis after tooth extraction, antibiotic prophylaxis is indicated to prevent recurrent osteonecrosis and promote healing of the extraction site. If chemotherapy-associated osteonecrosis is already present, antibiotic therapy is a vital part of conservative management to reduce the symptomatology of MRONJ and keep it from worsening. Finally, a lack of clinical data and randomized controlled trials makes it difficult to choose the most appropriate protocol for the various clinical situations studied.

Identifiers

PMID28149479
PMCPMC5268104
OpenAlexW2595468256

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.