Evidence map›Paper›PMID 28149335›Full record

ArticleClinical epigenetics2017

Esperanza Martín-Sánchez, Saioa Mendaza, Ane Ulazia-Garmendia, Iñaki Monreal-Santesteban, Alicia Córdoba, Francisco Vicente-García, Idoia Blanco-Luquin, Susana De La Cruz, Ana Aramendia, David Guerrero-Setas

Open access · goldAbstract read
In one paragraph

Article in Clinical epigenetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Esperanza Martín-SánchezCancer Epigenetics Group, Navarrabiomed. Departmento de Salud-UPNA. IdiSNA, Irunlarrea Road, 3, 31008 Pamplona, Spain.
Saioa MendazaCancer Epigenetics Group, Navarrabiomed. Departmento de Salud-UPNA. IdiSNA, Irunlarrea Road, 3, 31008 Pamplona, Spain.
Ane Ulazia-GarmendiaCancer Epigenetics Group, Navarrabiomed. Departmento de Salud-UPNA. IdiSNA, Irunlarrea Road, 3, 31008 Pamplona, Spain.
Iñaki Monreal-SantestebanCancer Epigenetics Group, Navarrabiomed. Departmento de Salud-UPNA. IdiSNA, Irunlarrea Road, 3, 31008 Pamplona, Spain.
Alicia CórdobaDepartment of Pathology, Complejo Hospitalario de Navarra, Irunlarrea Road, 3, 31008 Pamplona, Spain.
Francisco Vicente-GarcíaDepartment of Surgery, Complejo Hospitalario de Navarra, Pamplona, Spain.
Idoia Blanco-LuquinImmunomodulation Group, Navarrabiomed. Departmento de Salud-UPNA. IdiSNA, Pamplona, Spain.
Susana De La CruzDepartment of Medical Oncology, Complejo Hospitalario de Navarra, Pamplona, Spain.
Ana AramendiaBiobank of Navarrabiomed. Departmento de Salud-UPNA. IdiSNA, Pamplona, Spain.
David Guerrero-SetasCancer Epigenetics Group, Navarrabiomed. Departmento de Salud-UPNA. IdiSNA, Irunlarrea Road, 3, 31008 Pamplona, Spain.
Navarrabiomed · ESComplejo Hospitalario de Navarra · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCadherin-like protein 22 (CDH22) is a transmembrane glycoprotein involved in cell-cell adhesion and metastasis. Its role in cancer is controversial because it has been described as being upregulated in colorectal cancer, whereas it is downregulated in metastatic melanoma. However, its status in breast cancer (BC) is unknown. The purpose of our study was to determine the molecular status and clinical value of

resultsWe observed by immunohistochemistry that the level of CDH22 expression was lower in BC tissues than in their matched adjacent-to-tumour and non-neoplastic tissues from reduction mammoplasties. Since epigenetic alteration is one of the main causes of gene silencing, we analysed the hypermethylation of 3 CpG sites in the

conclusionsOur results are the first evidence that

Indexed as

DNA MethylationAdultAgedAged, 80 and overBreast NeoplasmsCadherinsCarcinoma, Ductal, BreastDown-RegulationEpigenesis, GeneticFemaleGene Expression Regulation, NeoplasticHumansMiddle AgedPrognosisPromoter Regions, GeneticSurvival AnalysisCadherinsCDH22 protein, humanBreast cancerCDH22DNA methylationPredictive biomarker

Identifiers

PMID28149335
PMCPMC5270318
OpenAlexW2582094534

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.