Evidence map›Paper›PMID 28149289›Full record

ArticleFrontiers in neurology2017

Pore-Forming Proteins as Mediators of Novel Epigenetic Mechanism of Epilepsy.

Andrei Surguchov, Irina Surgucheva, Mukut Sharma, Ram Sharma, Vikas Singh

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 51 citations in OpenAlex.

  1. Evaluation of Anti-epileptic Activity ofCentral nervous system agents in medicinal chemistry · 2026
    Article
  2. Article
  3. Role of Nrf2 in Epilepsy Treatment.Current molecular medicine · 2025
    Review
  4. Review
  5. Review
  6. The Role of α-Synuclein in Etiology of Neurodegenerative Diseases.International journal of molecular sciences · 2024
    Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Phenotypic Spectrum and Prognosis of Epilepsy Patients WithFrontiers in molecular neuroscience · 2022
    Article
  14. Dual Effects of Presynaptic Membrane Mimetics onFrontiers in cell and developmental biology · 2022
    Article
  15. Review
  16. Review
  17. Amyloid pores in mitochondrial membranes.Neural regeneration research · 2021
    Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Andrei SurguchovDepartment of Neurology, Kansas University Medical Center , Kansas City, KS , USA.
Irina SurguchevaDepartment of Neurology, Kansas University Medical Center , Kansas City, KS , USA.
Mukut SharmaKansas City Veterans Administration Medical Center, Kansas City, MO, USA; Midwest Biomedical Research Foundation, Kansas City, MO, USA.
Ram SharmaKansas City Veterans Administration Medical Center , Kansas City, MO , USA.
Vikas SinghDepartment of Neurology, Kansas University Medical Center, Kansas City, KS, USA; Kansas City Veterans Administration Medical Center, Kansas City, MO, USA.
University of Kansas Medical Center · USBiomedical Research Foundation · USUnited States Department of Veterans Affairs · USUniversity Medical Center · US

Funding

CYTOCHROME P-450 AND GLOMERULAR PROTEIN PERMEABILITYR01DK064969 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI MCCARTHY, ELLEN T · 2005 to 2010
$1.7M
BLRD VA I01 BX000361NIDDK NIH HHS R01 DK064969
6 · The paper itself

Abstract

Epilepsy is a disorder of the brain characterized by an enduring predisposition to generate epileptic seizures. In the last two decades, numerous gene defects underlying different forms of epilepsy have been identified with most of these genes encoding ion channel proteins. Despite these developments, the etiology of majority of non-familial epilepsies has no known associated genetic mutations and cannot be explained by defects in identified ion channels alone. We hypothesize that

Indexed as

epigenetic mechanismsepilepsyion channelsmicroRNAParkinson’s diseaseposttranslational modificationsstefin Bα-synuclein

Identifiers

PMID28149289
PMCPMC5241277
OpenAlexW2587047774

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.