ArticleThe Eurasian journal of medicine2016
Role of Procalcitonin in Evaluation of the Severity of Acute Cholecystitis.
Article in The Eurasian journal of medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Should Procalcitonin Be Included in Acute Cholecystitis Guidelines? A Systematic Review.Medicina (Kaunas, Lithuania) · 2023Pooled it
- Pooled it
- Diagnostic value of neutrophil CD64, procalcitonin, and interleukin-6 in sepsis: a meta-analysis.BMC infectious diseases · 2021Pooled it
- Clinical and Imaging Characteristics to Discriminate Between Complicated and Uncomplicated Acute Cholecystitis: A Regression Model and Decision Tree Analysis.Diagnostics (Basel, Switzerland) · 2025Article
- The role of serum and urıne neopterın levels on the determınatıon of acute cholecystıtıs severıty.European journal of medical research · 2025Article
- Evaluation of procalcitonin versus conventional inflammatory biomarkers for clinical severity grading in patients with intra-abdominal infection.Langenbeck's archives of surgery · 2025Article
- Procalcitonin and C-reactive protein as biomarkers for diagnosing and assessing the severity of acute cholecystitis.Open medicine (Warsaw, Poland) · 2025Article
- The Diagnosis and Treatment of Acute Cholecystitis: A Comprehensive Narrative Review for a Practical Approach.Journal of clinical medicine · 2024Review
- A case of granulocyte-colony-stimulating factor-producing gallbladder cancer with lymph node metastasis together with a literature review.Clinical journal of gastroenterology · 2023Review
- Management of Intra-Abdominal Infections: The Role of Procalcitonin.Antibiotics (Basel, Switzerland) · 2023Review
- An effective and reliable marker in gradıng the severity of acute cholecystitis: Increased immature granulocyte percentage.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2022Article
- Prognostic effect of Nesfatin-1 on the diagnosis and staging of acute cholecystitis.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2022Article
- Clinical Value of Neutrophil CD64 Index, PCT, and CRP in Acute Pancreatitis Complicated with Abdominal Infection.Diagnostics (Basel, Switzerland) · 2022Article
- Role of serum procalcitonin in predicting the surgical outcomes of acute calculous cholecystitis.Langenbeck's archives of surgery · 2021Article
- Can serum procalcitonin levels be useful in predicting spontaneous ureteral stone passage?BMC urology · 2020Observational
- Plasma Procalcitonin Is Useful for Predicting the Severity of Acute Cholecystitis.Emergency medicine international · 2020Article
- Role of procalcitonin as a predictor in difficult laparoscopic cholecystectomy for acute cholecystitis case: A retrospective study based on the TG18 criteria.Scientific reports · 2019Observational
- Sepsis and Septic Shock: Current Treatment Strategies and New Approaches.The Eurasian journal of medicine · 2017Review
- Article
- [Risk Factors Associated with Acute Gangrenous Cholecystitis].Acta gastroenterologica LatinoamericanaArticle
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study is to investigate the relationship between procalcitonin (PCT) level and the severity of acute cholecystitis. MATERIALS AND
methodsThis study included 200 patients diagnosed with acute cholecystitis. To diagnose and assess the severity of acute cholecystitis; physical examination and abdominal ultrasound findings were evaluated and blood samples were taken to determine white blood cell (WBC) count, erythrocyte sedimentation rate (ESR), and levels of coagulation factors, blood gas, C-reactive protein (CRP) and PCT. Patients were classified into three stages, namely, mild, moderate, and severe, according to the severity of acute cholecystitis using the Tokyo guidelines. The role of PCT level in the assessment of severity of acute cholecystitis and the correlation between the stages and PCT level were statistically analyzed.
resultsAmong patients with acute cholecystitis, 110 (55%) were classified as mild, 61 (30.5%) as moderate, and 29 (14.5%) as severe. Leukocytosis or leukopenia was positive in 48.5%, ESR elevation was found in 72.5%, CRP positivity in 55.5%, PCT elevation in 27%, and positive findings of ultrasonographic imaging in 54.5% of the patients. Serum WBC count, ESR, and CRP and PCT levels increased as the severity of disease increased (p<0.05). PCT could discriminate grade I from grade II-III with 95.45% sensitivity and 46.67% specificity at the best cut-off value of ≤0.52 (p<0.001). PCT could also discriminate grade III from grade I-II with 72.4% sensitivity and 90.06% specificity at the best cut-off value of >0.8 (p<0.001).
conclusionPCT level may be considered to be a parameter that could be added to the assessment of the severity of acute cholecystitis in the Tokyo guidelines, although further studies are needed to support our findings.
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