ReviewIndian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine2016
Thoughts on the current management of acute aluminum phosphide toxicity and proposals for therapy: An Evidence-based review.
Review in Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Potential role of paraffin oil gastric lavage in acute aluminum phosphide poisoning: a randomized controlled trial.Environmental science and pollution research international · 2022Trial
- Successful survival after severe aluminum phosphide poisoning complicated by cardiogenic shock, atrial fibrillation and severe metabolic acidosis: a case report.Journal of medical case reports · 2026Article
- Article
- Clinical, Biochemical, and Electrocardiographic Predictors of Mortality in Acute Aluminum Phosphide Poisoning.Journal of toxicology · 2026Article
- Considerations on the Management of Zinc Phosphide Toxicity and Proposed Therapeutic Approaches.JNMA; journal of the Nepal Medical Association · 2025Review
- The effect of educational programs on parents' knowledge, behavior, and practices regarding aluminum phosphide poisoning and its first-aid measures.BMC pediatrics · 2024Article
- Prognostic value of PGI score compared to poison severity score (PSS) and simplified acute physiology score (SAPS) II as predictors of mortality and other adverse outcomes in acute poisoning with aluminum phosphide.Toxicology reports · 2024Article
- The adjuvant effect of oil-based gastric lavage on the outcome of acute Aluminum phosphide poisoning: a systematic review and meta-analysis.Toxicology research · 2024Review
- Cardioprotective role of the coenzyme Q10 and coconut oil in acute aluminum phosphide poisoning: a randomized controlled clinical trial.Toxicology research · 2023Article
- Pattern and predictors of death from aluminum and zinc phosphide poisoning using multi-kernel optimized relevance vector machine.Scientific reports · 2023Article
- Refractory cardiogenic shock caused by zinc phosphide toxicity.Proceedings (Baylor University. Medical Center) · 2023Article
- The Role of Echocardiographic Findings in Estimating Survival Probability of Intensive Care Unit Admitted Aluminum Phosphide Poisoned Patients.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2022Article
- Hopeful News for Physicians Who Involved in the Treatment of Critical Aluminum Phosphide (Rice Pill) Poisoning Patients.Case reports in critical care · 2022Article
- Human Zinc Phosphide Exposure in Lebanon: A Case Report and Review of the Literature.Clinical practice and cases in emergency medicine · 2021Article
- The efficacy of Coenzyme Q10 and liquid paraffin oil in the management of acute aluminum phosphide poisoning.Toxicology research · 2020Article
- A study of the predictive factors of mortality in acute poisoning with aluminum phosphide with special reference to echocardiography and SOFA score.Environmental science and pollution research international · 2019Article
- Intravascular Hemolysis in Aluminum Phosphide Poisoning.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2019Article
- Extracorporeal membrane oxygenation in aluminum phosphide poisoning in Nepal: a case report.Journal of medical case reports · 2018Article
- Does N-acetyl Cysteine Have Protective Effects in Acute Aluminum Phosphide Poisoning?Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2017Article
- Cardiogenic Shock: The Main Cause of Mortality in Acute Aluminum Phosphide Poisoning.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2017Article
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The majority of aluminum phosphide (ALP) toxicity cases are suicidal attempts. Despite advances in critical care medicine, the mortality rate of ALP remains very high. Unfortunately, knowledge on the toxicokinetics of ALP is very low. An obsolete idea was proposed that inhibition of complex IV of cytochrome C oxidase is responsible for multiorgan dysfunction. However, based on human studies, this effect might be insignificant. Thus, a novel idea proposes that the main mechanism might be vascular wall integrity disruption. The low frequency of acute toxicity and unanswered questions about the toxicokinetics and toxicodynamics has led to leaden advances of novel treatments. The aim of this review was to evaluate problems regarding current treatment protocols and propose new ideas based on updated information. For this purpose, we reviewed all available articles on the management of ALP poisoning published to date. Considering failure of conventional therapies on maintaining systolic blood pressure, correcting acid-base disturbances, and support cardiac function, the previous treatment protocols have been overruled. However, repudiate of conventional treatments in this deadly condition is not without penalties for the health-care provider. The introduction of new therapies including refuse of gastric lavage with water-soluble compounds, administration of a high molecular weight colloidal solution for fluid resuscitation and termination using sodium bicarbonate, and vasoactive agents has been prospected to improve patient survival. This protocol is in early clinical evaluation; nevertheless, it appears to improve patient's survival; hence, future randomized trials should be performed to support their effectiveness.
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