ArticleOpen biology2017
The Notch pathway in the annelid Platynereis: insights into chaetogenesis and neurogenesis processes.
Article in Open biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 52 citations in OpenAlex.
- Multifaceted conserved functions of Notch during post-embryonic neurogenesis in the annelid Platynereis.EMBO reports · 2026Article
- Notch signaling in leech neurogenesis: expression patterns and functional insights in the Glossiphoniid leechAnimal cells and systems · 2026Article
- Predetermined sex revealed by a female transient gut in non-feeding larvae of Osedax (Siboglinidae, Annelida).EvoDevo · 2025Article
- Article
- Molluscan Shells, Spicules, and Gladii Are Evolutionarily Deeply Conserved.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2025Article
- De-novo transcriptome of anterior epimorphic regeneration in Perionyx excavatus.Scientific data · 2024Article
- Hooked on zombie worms? Genetic blueprints of bristle formation in Osedax japonicus (Annelida).EvoDevo · 2024Article
- Evolution and Function of the Notch Signaling Pathway: An Invertebrate Perspective.International journal of molecular sciences · 2024Review
- Role of cell rearrangement and related signaling pathways in the dynamic process of tip cell selection.Cell communication and signaling : CCS · 2024Review
- Transcriptomic landscape of posterior regeneration in the annelid Platynereis dumerilii.BMC genomics · 2023Article
- The cellular 3D printer of a marine bristle worm-chaetogenesis in Platynereis dumerilii (Audouin & Milne Edwards, 1834) (Annelida).Cell and tissue research · 2023Article
- Stage-Specific Transcriptomes of the MusselGenes · 2023Article
- A pan-metazoan concept for adult stem cells: the wobbling Penrose landscape.Biological reviews of the Cambridge Philosophical Society · 2022Article
- Novel Insights on Obligate Symbiont Lifestyle and Adaptation to Chemosynthetic Environment as Revealed by the Giant Tubeworm Genome.Molecular biology and evolution · 2022Article
- Studying Annelida Regeneration Using Platynereis dumerilii.Methods in molecular biology (Clifton, N.J.) · 2022Article
- The Nereid on the rise: Platynereis as a model system.EvoDevo · 2021Review
- RNA-Seq reveals divergent gene expression between larvae with contrasting trophic modes in the poecilogonous polychaete Boccardia wellingtonensis.Scientific reports · 2021Article
- Comparative and evolutionary analyses reveal conservation and divergence of the notch pathway in lophotrochozoa.Scientific reports · 2021Article
- Article
- Neurological Disorder Brain Model: A Lesson from Marine Worms (Annelida: Polychaeta).The Malaysian journal of medical sciences : MJMS · 2019Review
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Notch is a key signalling pathway playing multiple and varied functions during development. Notch regulates the selection of cells with a neurogenic fate and maintains a pool of yet uncommitted precursors through lateral inhibition, both in insects and in vertebrates. Here, we explore the functions of Notch in the annelid Platynereis dumerilii (Lophotrochozoa). Conserved components of the pathway are identified and a scenario for their evolution in metazoans is proposed. Unexpectedly, neither Notch nor its ligands are expressed in the neurogenic epithelia of the larva at the time when massive neurogenesis begins. Using chemical inhibitors and neural markers, we demonstrate that Notch plays no major role in the general neurogenesis of larvae. Instead, we find Notch components expressed in nascent chaetal sacs, the organs that produce the annelid bristles. Impairing Notch signalling induces defects in chaetal sac formation, abnormalities in chaetae producing cells and a change of identity of chaeta growth accessory cells. This is the first bilaterian species in which the early neurogenesis processes appear to occur without a major involvement of the Notch pathway. Instead, Notch is co-opted to pattern annelid-specific organs, likely through a lateral inhibition process. These features reinforce the view that Notch signalling has been recruited multiple times in evolution due to its remarkable 'toolkit' nature.
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