Evidence map›Paper›PMID 28148797›Full record

ArticleJournal of virology2017

Patterns of Cellular Immunity Associated with Experimental Infection with rDEN2Δ30 (Tonga/74) Support Its Suitability as a Human Dengue Virus Challenge Strain.

Alba Grifoni, Michael Angelo, John Sidney, Sinu Paul, Bjoern Peters, Aruna D de Silva, Elizabeth Phillips, Simon Mallal, Sean A Diehl, Jason Botten and 6 more

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 23 citations in OpenAlex.

  1. Safety and Immunogenicity of an AS03The American journal of tropical medicine and hygiene · 2020
    Trial
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Understanding dengue virus evolution to support epidemic surveillance and counter-measure development.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2018
    Review
  14. Article
  15. Global Assessment of Dengue Virus-Specific CD4Frontiers in immunology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 3 countries.

Alba GrifoniDivision of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA.
Michael AngeloDivision of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA.
John SidneyDivision of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA.
Sinu PaulDivision of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA.
Bjoern PetersDivision of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA.
Aruna D de SilvaDivision of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA.
Elizabeth PhillipsInstitute for Immunology and Infectious Diseases, Murdoch University, Perth, Western Australia, Australia, and Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Simon MallalInstitute for Immunology and Infectious Diseases, Murdoch University, Perth, Western Australia, Australia, and Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Sean A DiehlUniversity of Vermont College of Medicine and Vaccine Testing Center, Burlington, Vermont, USA.
Jason BottenUniversity of Vermont College of Medicine and Vaccine Testing Center, Burlington, Vermont, USA.
Jonathan BoysonUniversity of Vermont College of Medicine and Vaccine Testing Center, Burlington, Vermont, USA.
Beth D KirkpatrickUniversity of Vermont College of Medicine and Vaccine Testing Center, Burlington, Vermont, USA.
Stephen S WhiteheadNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Anna P DurbinJohns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.
Alessandro SetteDivision of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA.
Daniela WeiskopfDivision of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA daniela@lji.org.
La Jolla Institute for Immunology · USUniversity of Vermont · USGenetech (Sri Lanka) · LKJohns Hopkins University · USMurdoch University · AUNational Institute of Allergy and Infectious Diseases · USVanderbilt University · US

Funding

Clinical Trials of Biodefense Vaccines (Dengue, West Nile Virus, TBEV)ZIAAI000987 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI WHITEHEAD, STEPHEN · 2009 to 2025
$37.9M
Understanding and preventing HLA-associated drug reactionsP50GM115305 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PHILLIPS, ELIZABETH · 2015 to 2019
$13.0M
NIAID NIH HHS HHSN272200900042CNIAID NIH HHS HHSN272201400045CNIGMS NIH HHS P50 GM115305
6 · The paper itself

Abstract

A deletion variant of the dengue virus (DENV) serotype 2 (DENV2) Tonga/74 strain lacking 30 nucleotides from its 3' untranslated region (rDEN2Δ30) has previously been established for use in a controlled human DENV challenge model. To evaluate if this model is appropriate for the derivation of correlates of protection for DENV vaccines on the basis of cellular immunity, we wanted to compare the cellular immune response to this challenge strain to the response induced by natural infection. To achieve this, we predicted HLA class I- and class II-restricted peptides from rDEN2Δ30 and used them in a gamma interferon enzyme-linked immunosorbent spot assay to interrogate CD8

Indexed as

3' Untranslated RegionsAntigens, ViralCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesDengueDengue VirusEnzyme-Linked Immunospot AssayEpitopesHumansInterferon-gammaSequence Deletion3' Untranslated RegionsAntigens, ViralEpitopesInterferon-gammadengue virushuman challenge modelT cellsvaccine

Identifiers

PMID28148797
PMCPMC5375662
OpenAlexW2583718411

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.