Evidence map›Paper›PMID 28148630›Full record

ArticleNeurology2017

Dysarthria and broader motor speech deficits in Dravet syndrome.

Samantha J Turner, Amy Brown, Marta Arpone, Vicki Anderson, Angela T Morgan, Ingrid E Scheffer

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 33 citations in OpenAlex.

  1. Trial
  2. Randomized Controlled Trial of Melatonin for Sleep Disturbance in Dravet Syndrome: The DREAMS Study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2018
    Trial
  3. Article
  4. Article
  5. Review
  6. Article
  7. Developmental and epileptic encephalopathies.Nature reviews. Disease primers · 2024
    Review
  8. Review
  9. Article
  10. Article
  11. Toward the Language Oscillogenome.Frontiers in psychology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Samantha J TurnerFrom the Department of Paediatrics, The University of Melbourne (S.J.T., M.A., V.A., A.T.M., I.E.S.), and Department of Psychology (V.A.), The Royal Children's Hospital; Neuroscience of Speech Group, Clinical Sciences Theme (S.J.T., A.T.M.), Australian Centre for Child Neuropsychological Studies (A.B., M.A., V.A.), Murdoch Childrens Research Institute, Melbourne; Epilepsy Research Centre, Department of Medicine (I.E.S.), The University of Melbourne, Austin Health; and Florey Institute of Neuroscience and Mental Health (I.E.S.), Melbourne, Australia.
Amy BrownFrom the Department of Paediatrics, The University of Melbourne (S.J.T., M.A., V.A., A.T.M., I.E.S.), and Department of Psychology (V.A.), The Royal Children's Hospital; Neuroscience of Speech Group, Clinical Sciences Theme (S.J.T., A.T.M.), Australian Centre for Child Neuropsychological Studies (A.B., M.A., V.A.), Murdoch Childrens Research Institute, Melbourne; Epilepsy Research Centre, Department of Medicine (I.E.S.), The University of Melbourne, Austin Health; and Florey Institute of Neuroscience and Mental Health (I.E.S.), Melbourne, Australia.
Marta ArponeFrom the Department of Paediatrics, The University of Melbourne (S.J.T., M.A., V.A., A.T.M., I.E.S.), and Department of Psychology (V.A.), The Royal Children's Hospital; Neuroscience of Speech Group, Clinical Sciences Theme (S.J.T., A.T.M.), Australian Centre for Child Neuropsychological Studies (A.B., M.A., V.A.), Murdoch Childrens Research Institute, Melbourne; Epilepsy Research Centre, Department of Medicine (I.E.S.), The University of Melbourne, Austin Health; and Florey Institute of Neuroscience and Mental Health (I.E.S.), Melbourne, Australia.
Vicki AndersonFrom the Department of Paediatrics, The University of Melbourne (S.J.T., M.A., V.A., A.T.M., I.E.S.), and Department of Psychology (V.A.), The Royal Children's Hospital; Neuroscience of Speech Group, Clinical Sciences Theme (S.J.T., A.T.M.), Australian Centre for Child Neuropsychological Studies (A.B., M.A., V.A.), Murdoch Childrens Research Institute, Melbourne; Epilepsy Research Centre, Department of Medicine (I.E.S.), The University of Melbourne, Austin Health; and Florey Institute of Neuroscience and Mental Health (I.E.S.), Melbourne, Australia.
Angela T MorganFrom the Department of Paediatrics, The University of Melbourne (S.J.T., M.A., V.A., A.T.M., I.E.S.), and Department of Psychology (V.A.), The Royal Children's Hospital; Neuroscience of Speech Group, Clinical Sciences Theme (S.J.T., A.T.M.), Australian Centre for Child Neuropsychological Studies (A.B., M.A., V.A.), Murdoch Childrens Research Institute, Melbourne; Epilepsy Research Centre, Department of Medicine (I.E.S.), The University of Melbourne, Austin Health; and Florey Institute of Neuroscience and Mental Health (I.E.S.), Melbourne, Australia.
Ingrid E SchefferFrom the Department of Paediatrics, The University of Melbourne (S.J.T., M.A., V.A., A.T.M., I.E.S.), and Department of Psychology (V.A.), The Royal Children's Hospital; Neuroscience of Speech Group, Clinical Sciences Theme (S.J.T., A.T.M.), Australian Centre for Child Neuropsychological Studies (A.B., M.A., V.A.), Murdoch Childrens Research Institute, Melbourne; Epilepsy Research Centre, Department of Medicine (I.E.S.), The University of Melbourne, Austin Health; and Florey Institute of Neuroscience and Mental Health (I.E.S.), Melbourne, Australia. scheffer@unimelb.edu.au.
Austin Health · AURoyal Children's Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo analyze the oral motor, speech, and language phenotype in 20 children and adults with Dravet syndrome (DS) associated with mutations in

methodsFifteen verbal and 5 minimally verbal DS patients with

resultsSpeech was characterized by imprecise articulation, abnormal nasal resonance, voice, and pitch, and prosody errors. Half of verbal patients had moderate to severely impaired conversational speech intelligibility. Oral motor impairment, motor planning/programming difficulties, and poor postural control were typical. Nonverbal individuals had intentional communication. Cognitive skills varied markedly, with intellectual functioning ranging from the low average range to severe intellectual disability. Language impairment was congruent with cognition.

conclusionsWe describe a distinctive speech, language, and oral motor phenotype in children and adults with DS associated with mutations in

Indexed as

AdolescentAdultChildChild, PreschoolCohort StudiesDysarthriaDyskinesiasEpilepsies, MyoclonicFemaleHumansInfantLanguageMaleMotor SkillsMutationNAV1.1 Voltage-Gated Sodium ChannelNAV1.1 Voltage-Gated Sodium ChannelSCN1A protein, human

Identifiers

PMID28148630
PMCPMC5344083
OpenAlexW2585652737

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.