ArticleBMC medical research methodology2017
Motivations for (non)participation in population-based health studies among the elderly - comparison of participants and nonparticipants of a prospective study on influenza vaccination.
Article in BMC medical research methodology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Trial
- Establishment of a cohort for deep phenotyping of the immune response to influenza vaccination among elderly individuals recruited from the general population.Human vaccines & immunotherapeutics · 2017Trial
- Interferon-related inflammaging links epigenetic age acceleration to multimorbidity.Cell genomics · 2026Article
- Systemic dysregulation and molecular insights into poor influenza vaccine response in the aging population.Science advances · 2024Article
- Public attitudes towards personal health data sharing in long-term epidemiological research: a Citizen Science approach in the KORA study.BMC public health · 2024Article
- Participation and engagement in online cognitive testing.Scientific reports · 2024Article
- Senior Health Clinic for 75-year-old home-dwelling Finns - study design, clinic protocol and non-response analysis.BMC health services research · 2023Article
- Factors affecting willingness to participate in vaccine clinical trials in an underdeveloped country: perspective from Nepal.Human vaccines & immunotherapeutics · 2022Article
- Distinct immunological and molecular signatures underpinning influenza vaccine responsiveness in the elderly.Nature communications · 2022Article
- Recruiting Adolescent and Young Adult Cancer Survivors for Patient-Reported Outcome Research: Experiences and Sample Characteristics of the SURVAYA Study.Current oncology (Toronto, Ont.) · 2022Article
- Participants' Comprehension of the Informed Consent in an Epidemiological Study on Dementia Prevalence: A Qualitative Study.Frontiers in psychiatry · 2021Article
- Article
- Decision-Making And Selection Bias in Four Observational Studies on Duchenne and Becker Muscular Dystrophy.Journal of neuromuscular diseases · 2020Article
- A research tool for measuring non-participation of older people in research on digital health.BMC public health · 2019Review
- Self-reported diabetes and herpes zoster are associated with a weak humoral response to the seasonal influenza A H1N1 vaccine antigen among the elderly.BMC infectious diseases · 2019Observational
- Willingness to Participate in Vaccine-Related Clinical Trials among Older Adults.International journal of environmental research and public health · 2018Article
- Why do people participate in health-related studies?International journal of public health · 2017Article
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundParticipation in epidemiological studies has strongly declined in recent years. We examined the reasons for (non)participation in population-based health studies among participants and nonparticipants of a prospective study on influenza vaccination among the elderly.
methodsMales and females between 65 and 80 years of age (N = 5582) were randomly selected from the residents' registration office in Hannover, Germany, and were invited to participate in a study featuring vaccination with a seasonal adjuvanted influenza vaccine (Fluad™, Novartis) including five follow-up visits (day 0, 1/3, 7, 21, 70 with respect to vaccination). A 24-item nonresponder questionnaire, including 10 items on reasons for participating in a hypothetical health study, was mailed to 1500 randomly selected nonparticipants. The same 10 items were included in the end-of-study questionnaire administered to the participants in the vaccination study (n = 200). Logistic regression analysis with backward elimination was used to identify the reasons most strongly associated with nonparticipation.
resultsFive hundred thirty-one (35%) nonparticipants and 200 participants (100%) returned the respective questionnaires. Nonparticipation was associated with a lower interest in obtaining personal health information (OR = 3.32) and a preference for less invasive (OR = 3.01) and less time-demanding (OR = 2.19) studies. Responses to other items, e.g. regarding altruistic motives, monetary compensation, general interest of the study, or study approval through ethics committee and data security authority, did not differ between participants and nonparticipants.
conclusionsParticipation rates in health studies among elderly individuals could potentially be improved by reducing interventions and time demand, for instance by implementing methods of self-sampling and remote data collection.
trial registrationNo. 1100359 (ClinicalTrials.gov, date of registration: 09.02.2015).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.