ArticleCell reports2017
Serotonin Signaling through Prefrontal Cortex 5-HT
Open access · goldAbstract read
In one paragraph
Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 59 citations in OpenAlex.
- Serotonergic modulation of excitatory synapse development and plasticity.Molecules and cells · 2026Review
- Prefrontal Cortex Dysfunction as a Precipitating Factor for Schizophrenia and Depression.Journal of neurochemistry · 2026Review
- The influence of serotonergic multilocus genetic variants and parent-child relationship on adolescent creativity.Scientific reports · 2025Article
- Male-biased vulnerability of mouse brain tryptophan/kynurenine and glutamate systems to adolescent exposures to concentrated ambient ultrafine particle air pollution.Neurotoxicology · 2024Article
- Distinct ACC Neural Mechanisms Underlie Authentic and Transmitted Anxiety Induced by Maternal Separation in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- The Effects of Chronic Unpredictable Mild Stress and Semi-Pure Diets on the Brain, Gut and Adrenal Medulla in C57BL6 Mice.International journal of molecular sciences · 2023Article
- Anxiety and depression: A top-down, bottom-up model of circuit function.Annals of the New York Academy of Sciences · 2023Review
- Inhibition of norepinephrine signaling during a sensitive period disrupts locus coeruleus circuitry and emotional behaviors in adulthood.Scientific reports · 2023Article
- Serotonin disruption at gestation alters expression of genes associated with serotonin synthesis and reuptake at weaning.Psychopharmacology · 2022Article
- Sex-based changes in rat brain serotonin and behavior in a model of altitude-related vulnerability to treatment-resistant depression.Psychopharmacology · 2021Article
- Sex-Based Impact of Creatine Supplementation on Depressive Symptoms, Brain Serotonin and SSRI Efficacy in an Animal Model of Treatment-Resistant Depression.International journal of molecular sciences · 2021Article
- Depression, dementia and immune dysregulation.Brain : a journal of neurology · 2021Article
- Pivotal mental states.Journal of psychopharmacology (Oxford, England) · 2021Review
- Mental Resilience and Coping With Stress: A Comprehensive, Multi-level Model of Cognitive Processing, Decision Making, and Behavior.Frontiers in behavioral neuroscience · 2021Article
- Transient serotonin depletion at adolescence, but not at early infancy, reduced subsequent anxiety-like behavior and alcohol intake in female mice.Psychopharmacology · 2021Article
- Medial PFC AMPA receptor and BDNF signaling are required for the rapid and sustained antidepressant-like effects of 5-HTNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Perinatal fluoxetine exposure disrupts the circadian response to a phase-shifting challenge in female rats.Psychopharmacology · 2020Article
- Pharmacological Studies on the Role of 5-HTFrontiers in behavioral neuroscience · 2020Article
- Dopamine DThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Genetic, epigenetic and posttranscriptional mechanisms for treatment of major depression: the 5-HT1A receptor gene as a paradigmJournal of psychiatry & neuroscience : JPN · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Alvaro L Garcia-GarciaDranovsky-Leonardo (ADL) Lab, Division of Integrative Neuroscience, Department of Psychiatry, Columbia University and the New York State Psychiatric Institute, 1051 Riverside Dr., Box 87, New York, NY 10032, USA.
Qingyuan MengDranovsky-Leonardo (ADL) Lab, Division of Integrative Neuroscience, Department of Psychiatry, Columbia University and the New York State Psychiatric Institute, 1051 Riverside Dr., Box 87, New York, NY 10032, USA.
Sarah CanettaDepartment of Psychiatry, Columbia University, New York, NY 10032, USA.
Alain M GardierCESP, University Paris-Sud, Fac. Pharmacie, INSERM, Université Paris-Saclay, Chatenay-Malabry 91290, France.
Bruno P GuiardCESP, University Paris-Sud, Fac. Pharmacie, INSERM, Université Paris-Saclay, Chatenay-Malabry 91290, France.
Christoph KellendonkDepartment of Psychiatry, Columbia University, New York, NY 10032, USA; Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY 10032, USA; Department of Anesthesiology, Columbia University Medical Center, New York, NY 10032, USA.
Alex DranovskyDranovsky-Leonardo (ADL) Lab, Division of Integrative Neuroscience, Department of Psychiatry, Columbia University and the New York State Psychiatric Institute, 1051 Riverside Dr., Box 87, New York, NY 10032, USA. Electronic address: ad722@cumc.columbia.edu.
E David LeonardoDranovsky-Leonardo (ADL) Lab, Division of Integrative Neuroscience, Department of Psychiatry, Columbia University and the New York State Psychiatric Institute, 1051 Riverside Dr., Box 87, New York, NY 10032, USA. Electronic address: el367@cumc.columbia.edu.
Columbia University · USNew York State Psychiatric InstituteUniversité Paris-Saclay · FRNew York Psychoanalytic Society and Institute · US
Funding
Neural mechanisms of increased anxiety in serotonin 1A receptor-deficient miceR01MH081968 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LEONARDO, EDUARDO DAVID · 2008 to 2017
$3.7MMechanisms and Significance of Stem Cell Fate Plasticity in the Adult HippocampusR01MH091844 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI DRANOVSKY, ALEX · 2010 to 2014
$2.0MDevelopmental regulation of mood states by 5-HT1A heteroreceptorsR01MH105675 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI LEONARDO, EDUARDO DAVID · 2015 to 2017
$1.6MTemporal specification of neuronal function and its relevance to mental health.R56MH106809 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI DRANOVSKY, ALEX · 2016 to 2017
$1.1MEffects of maternal immune activation on offspring GABA circuitry and behaviorK01MH107760 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI CANETTA, SARAH E · 2016 to 2019
$732kNIMH NIH HHS K01 MH107760NIMH NIH HHS R01 MH081968NIMH NIH HHS R01 MH091844NIMH NIH HHS R01 MH105675NIMH NIH HHS R56 MH106809
Abstract
Lifelong homeostatic setpoints for mood-related behaviors emerge during adolescence. Serotonin (5-HT) plays an important role in refining the formation of brain circuits during sensitive developmental periods. In rodents, the role of 5-HT
Indexed as
AffectAnimalsAnxietyAutoreceptorsBehavior, AnimalDepressionDorsal Raphe NucleusMaleMicePrefrontal CortexReceptor, Serotonin, 5-HT1ASerotoninSignal TransductionAutoreceptorsReceptor, Serotonin, 5-HT1ASerotonin5-HT(1A)adolescenceanxietydepressiondevelopmentDRNmPFCserotonin
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.