ArticleCell reports2017
Abnormal Development of the Earliest Cortical Circuits in a Mouse Model of Autism Spectrum Disorder.
Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Auditory processing in rodent models of autism: a systematic review.Journal of neurodevelopmental disorders · 2022Pooled it
- Changing subplate circuits: Early activity dependent circuit plasticity.Frontiers in cellular neuroscience · 2022Pooled it
- Self-vocalizations activate the developing auditory cortex via an intracortical pathway.Science advances · 2026Article
- Beyond diagnostic categories: sensory processing as a transdiagnostic mechanism in autism, ADHD, and PTSD - a neuropsychoanalytic conceptual analysis.Frontiers in psychology · 2026Review
- Recovery of centralities in medial prefrontal and sensory-related cortices associated with social behavior improvements in an autism mouse model.Scientific reports · 2025Article
- Disrupted functional connectome in a rodent model of autism during social isolation.Frontiers in neural circuits · 2025Article
- Increased Serotonin Levels and Unchanged Glutamate and GABA Levels in Thalamic Microdialysates Despite Reduced Cell Numbers in a Valproic Acid-Induced Autism Model.Neurochemical research · 2024Article
- Molecular Lineages and Spatial Distributions of Subplate Neurons in the Human Fetal Cerebral Cortex.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Trans Species RNA Activity: Sperm RNA of the Father of an Autistic Child Programs Glial Cells and Behavioral Disorders in Mice.Biomolecules · 2024Article
- Altered Developmental Trajectory in Male and Female Rats in a Prenatal Valproic Acid Exposure Model of Autism Spectrum Disorder.Journal of autism and developmental disorders · 2023Article
- Celf4 controls mRNA translation underlying synaptic development in the prenatal mammalian neocortex.Nature communications · 2023Article
- Early retinal deprivation crossmodally alters nascent subplate circuits and activity in the auditory cortex during the precritical period.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Developmental changes in electrophysiological properties of auditory cortical neurons in theJournal of neurophysiology · 2023Article
- Axonal connections between S1 barrel, M1, and S2 cortex in the newborn mouse.Frontiers in neuroanatomy · 2023Article
- Sleep Problems in Preschoolers With Autism Spectrum Disorder Are Associated With Sensory Sensitivities and Thalamocortical Overconnectivity.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Article
- The Antiepileptic Drug and Toxic Teratogen Valproic Acid Alters Microglia in an Environmental Mouse Model of Autism.Toxics · 2022Article
- Impaired Hearing and Altered Subplate Circuits During the First and Second Postnatal Weeks of Otoferlin-Deficient Mice.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Neonatal Hypoxia-Ischemia Causes Persistent Intracortical Circuit Changes in Layer 4 of Rat Auditory Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Early brain activity: Translations between bedside and laboratory.Progress in neurobiology · 2022Review
- Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Autism spectrum disorder (ASD) involves deficits in speech and sound processing. Cortical circuit changes during early development likely contribute to such deficits. Subplate neurons (SPNs) form the earliest cortical microcircuits and are required for normal development of thalamocortical and intracortical circuits. Prenatal valproic acid (VPA) increases ASD risk, especially when present during a critical time window coinciding with SPN genesis. Using optical circuit mapping in mouse auditory cortex, we find that VPA exposure on E12 altered the functional excitatory and inhibitory connectivity of SPNs. Circuit changes manifested as "patches" of mostly increased connection probability or strength in the first postnatal week and as general hyper-connectivity after P10, shortly after ear opening. These results suggest that prenatal VPA exposure severely affects the developmental trajectory of cortical circuits and that sensory-driven activity may exacerbate earlier, subtle connectivity deficits. Our findings identify the subplate as a possible common pathophysiological substrate of deficits in ASD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.