ArticleBritish journal of pharmacology2017
Pharmacological characterization of the excitatory 'Cys-loop' GABA receptor family in Caenorhabditis elegans.
Article in British journal of pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 8 citations in OpenAlex.
- Ivermectin Toxicity in Humans and Animals: Clinical Spectrum, Mechanisms, and Management.Journal of applied toxicology : JAT · 2026Review
- Multiple combinations of RDL subunits diversify the repertoire of GABA receptors in the honey bee parasiteThe Journal of biological chemistry · 2018Article
- Highly Efficient, Rapid and Co-CRISPR-Independent Genome Editing inG3 (Bethesda, Md.) · 2017Article
- Pharmacological characterization of the excitatory 'Cys-loop' GABA receptor family in Caenorhabditis elegans.British journal of pharmacology · 2017Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
background and purposeIonotropic GABA receptors are evolutionarily conserved proteins that mediate cellular and network inhibition in both vertebrates and invertebrates. A unique class of excitatory GABA receptors has been identified in several nematode species. Despite well-characterized functions in Caenorhabditis elegans, little is known about the pharmacology of the excitatory GABA receptors EXP-1 and LGC-35. Using a panel of compounds that differentially activate and modulate ionotropic GABA receptors, we investigated the agonist binding site and allosteric modulation of EXP-1 and LGC-35. EXPERIMENTAL APPROACH: We used two-electrode voltage clamp recordings to characterize the pharmacological profile of EXP-1 and LGC-35 receptors expressed in Xenopus laevis oocytes. KEY
resultsThe pharmacology of EXP-1 and LGC-35 is different from that of GABA CONCLUSIONS AND IMPLICATIONS: The pharmacological properties of EXP-1 and LGC-35 more closely resemble the ionotropic GABA
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.