ArticleOptics letters2017
Reflectance-mode interferometric near-infrared spectroscopy quantifies brain absorption, scattering, and blood flow index in vivo.
Article in Optics letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- CoMind R1: a time-resolved interferometric optical neuromonitoring system for pulsatile cerebral blood flow measurement at late times-of-flight.Neurophotonics · 2026Article
- Tutorial on methods for estimation of optical absorption and scattering properties of tissue.Journal of biomedical optics · 2024Article
- Interferometric near-infrared spectroscopy (iNIRS) reveals that blood flow index depends on wavelength.Biomedical optics express · 2024Article
- Interferometric diffusing wave spectroscopy imaging with an electronically variable time-of-flight filter.Optica · 2023Article
- Interferometric diffuse optics: recent advances and future outlook.Neurophotonics · 2023Article
- Continuous-wave parallel interferometric near-infrared spectroscopy (CWBiomedical optics express · 2022Article
- Performance assessment of laser sources for time-domain diffuse correlation spectroscopy.Biomedical optics express · 2021Article
- Time-domain diffuse correlation spectroscopy (TD-DCS) for noninvasive, depth-dependent blood flow quantification in human tissue in vivo.Scientific reports · 2021Article
- Beyond diffuse correlations: deciphering random flow in time-of-flight resolved light dynamics.Optics express · 2020Article
- Time-of-flight resolved light field fluctuations reveal deep human tissue physiology.Nature communications · 2020Article
- Effects of the instrument response function and the gate width in time-domain diffuse correlation spectroscopy: model and validations.Neurophotonics · 2019Article
- Correlation gating quantifies the optical properties of dynamic media in transmission.Optics letters · 2018Article
- Highly parallel, interferometric diffusing wave spectroscopy for monitoring cerebral blood flow dynamics.Optica · 2018Article
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
Interferometric near-infrared spectroscopy (iNIRS) is a new technique that measures time-of-flight- (TOF-) resolved autocorrelations in turbid media, enabling simultaneous estimation of optical and dynamical properties. Here, we demonstrate reflectance-mode iNIRS for noninvasive monitoring of a mouse brain in vivo. A method for more precise quantification with less static interference from superficial layers, based on separating static and dynamic components of the optical field autocorrelation, is presented. Absolute values of absorption, reduced scattering, and blood flow index (BFI) are measured, and changes in BFI and absorption are monitored during a hypercapnic challenge. Absorption changes from TOF-resolved iNIRS agree with absorption changes from continuous wave NIRS analysis, based on TOF-integrated light intensity changes, an effective path length, and the modified Beer-Lambert Law. Thus, iNIRS is a promising approach for quantitative and noninvasive monitoring of perfusion and optical properties in vivo.
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