Evidence map›Paper›PMID 28146351›Full record

ArticleBiomacromolecules2017

Implantable Tin Porphyrin-PEG Hydrogels with pH-Responsive Fluorescence.

Haoyuan Huang, Saurabh Chauhan, Jumin Geng, Yiru Qin, David F Watson, Jonathan F Lovell

Abstract read
In one paragraph

Article in Biomacromolecules, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 36 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Haoyuan HuangDepartment of Biomedical Engineering and ‡Department of Chemistry, University at Buffalo, State University of New York , Buffalo, New York 14260, United States.
Saurabh ChauhanDepartment of Biomedical Engineering and ‡Department of Chemistry, University at Buffalo, State University of New York , Buffalo, New York 14260, United States.
Jumin GengDepartment of Biomedical Engineering and ‡Department of Chemistry, University at Buffalo, State University of New York , Buffalo, New York 14260, United States.
Yiru QinDepartment of Biomedical Engineering and ‡Department of Chemistry, University at Buffalo, State University of New York , Buffalo, New York 14260, United States.
David F WatsonDepartment of Biomedical Engineering and ‡Department of Chemistry, University at Buffalo, State University of New York , Buffalo, New York 14260, United States.ORCID 0000-0003-1203-2811
Jonathan F LovellDepartment of Biomedical Engineering and ‡Department of Chemistry, University at Buffalo, State University of New York , Buffalo, New York 14260, United States.ORCID 0000-0002-9052-884X
University at Buffalo, State University of New York · US

Funding

Targeting Tumors with Resealable Nanovesicles Permeabilized by NIR LightDP5OD017898 · OD · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI LOVELL, JONATHAN F · 2013 to 2017
$1.9M
NIH HHS DP5 OD017898
6 · The paper itself

Abstract

Tetracarboxy porphyrins can be polymerized with polyethylene glycol (PEG) diamines to generate hydrogels with intense, near-infrared, and transdermal fluorescence following subcutaneous implantation. Here, we show that the high density porphyrins of the preformed polymer can be chelated with tin via simple incubation. Tin porphyrin hydrogels exhibited increasing emission intensities, ratios, and lifetimes from pH 1 to 10. Tin porphyrin hydrogel emission was strongly reversible and pH responsiveness was observed in the physiological range between pH 6 and pH 8. pH-sensitive emission was detected via noninvasive transdermal fluorescence imaging in vivo following subcutaneous implantation in mice.

Indexed as

FluorescenceAnimalsHydrogelsHydrogen-Ion ConcentrationMicePolyethylene GlycolsPolymersPorphyrinsProstheses and ImplantsSpectrometry, FluorescenceTinHydrogelsPolyethylene GlycolsPolymersPorphyrinsTin

Identifiers

PMID28146351
PMCPMC6232081
OpenAlexW2585010107

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.