SynthesisInternational journal of geriatric psychiatry2017
Dementia and co-occurring chronic conditions: a systematic literature review to identify what is known and where are the gaps in the evidence?
Synthesis in International journal of geriatric psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.
- The Italian guideline on diagnosis and treatment of dementia and mild cognitive impairment.Age and ageing · 2024Guideline
- Burden and care time for dementia caregivers in the LIVE@Home.Path trial.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Trial
- Data-driven subtyping of Alzheimer's emergency presentations using unsupervised machine learning.IBRO neuroscience reports · 2026Article
- Home-Based Digital Healthcare Interventions for Dementia: A Systematic Review of Patient and Family Caregiver Outcomes.Healthcare (Basel, Switzerland) · 2026Review
- Adaptation and psychometric validation of treatment burden questionnaire for caregivers of older adults with diabetes and dementia.Aging & mental health · 2026Article
- Exacerbation of racial disparities in COVID-19 outcomes by Alzheimer's disease and related dementias among nursing home residents.American journal of epidemiology · 2026Article
- Difficulty with taking medications and the future risk of Alzheimer's disease and related dementias: Health and Retirement Study of Americans.American journal of neurodegenerative disease · 2026Article
- Methods of Engaging Interest-Holders in Healthcare Evidence Syntheses: A Scoping Review.Cochrane evidence synthesis and methods · 2026Review
- Prevalence of Chronic Diseases by Cognitive Function Level and Age Group Among Middle-Aged and Older Korean Adults.International journal of geriatric psychiatry · 2025Article
- Ambulatory Care Sensitive Hospitalizations and Disparities Among Older Adults With Dementia Before and During the Pandemic.Journal of the American Geriatrics Society · 2025Observational
- Multimorbidity in dementia: Current perspectives and future challenges.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Implementing early detection of cognitive impairment in primary care to improve care for older adults.Journal of internal medicine · 2025Review
- Medication Management Difficulty, Medication Nonadherence, and Risk of Hospitalization Among Cognitively Impaired Older Americans: A Nationally Representative Study.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2025Article
- Forecasted Dementia Prevalence in Portugal (2020-2080).Journal of geriatric psychiatry and neurology · 2024Article
- Racial and ethnic differences in telemedicine use among community-dwelling older adults with dementia.Journal of the American Geriatrics Society · 2024Article
- External Validation of the Charlson Comorbidity Index-based Model for Survival Prediction in Thai Patients Diagnosed with Dementia.BMC geriatrics · 2024Article
- Personal Health Planning in Adult-Child Former Caregivers of Parents Living With Dementia.American journal of health promotion : AJHP · 2024Article
- Caregivers' Burden on Patients with Dementia Having Multiple Chronic Diseases.Risk management and healthcare policy · 2024Article
- Self-administered gerocognitive examination (SAGE) aids early detection of cognitive impairment at primary care provider visits.Frontiers in medicine · 2024Article
- Associations Between Cognitive Impairment Severity and Barriers to Healthcare Engagement Among Older Adults.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 7 institutions in 1 country.
Funding
Abstract
objectiveThe challenges posed by people living with multiple chronic conditions are unique for people with dementia and other significant cognitive impairment. There have been recent calls to action to review the existing literature on co-occurring chronic conditions and dementia in order to better understand the effect of cognitive impairment on disease management, mobility, and mortality.
methodsThis systematic literature review searched PubMed databases through 2011 (updated in 2016) using key constructs of older adults, moderate-to-severe cognitive impairment (both diagnosed and undiagnosed dementia), and chronic conditions. Reviewers assessed papers for eligibility and extracted key data from each included manuscript. An independent expert panel rated the strength and quality of evidence and prioritized gaps for future study.
resultsFour thousand thirty-three articles were identified, of which 147 met criteria for review. We found that moderate-to-severe cognitive impairment increased risks of mortality, was associated with prolonged institutional stays, and decreased function in persons with multiple chronic conditions. There was no relationship between significant cognitive impairment and use of cardiovascular or hypertensive medications for persons with these comorbidities. Prioritized areas for future research include hospitalizations, disease-specific outcomes, diabetes, chronic pain, cardiovascular disease, depression, falls, stroke, and multiple chronic conditions.
conclusionsThis review summarizes that living with significant cognitive impairment or dementia negatively impacts mortality, institutionalization, and functional outcomes for people living with multiple chronic conditions. Our findings suggest that chronic-disease management interventions will need to address co-occurring cognitive impairment. Copyright © 2017 John Wiley & Sons, Ltd.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.