ArticleInvestigative ophthalmology & visual science2017
Collagen Architecture of the Posterior Pole: High-Resolution Wide Field of View Visualization and Analysis Using Polarized Light Microscopy.
Article in Investigative ophthalmology & visual science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 1 of them a synthesis that pooled it.
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Who cites it
68 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Critical Systematic Review of 3D Bioprinting in Biomedicine.International journal of molecular sciences · 2025Pooled it
- The Strain Response to Intraocular Pressure Decrease in the Lamina Cribrosa of Patients with Glaucoma.Ophthalmology. GlaucomaTrial
- Real-Time Ferroelectric Domain Wall Dynamics During Electric Poling and Depoling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Possible Extension of Inner Scleral Fibers Into the Peripapillary Sclera Detected by Polarization-Sensitive OCT.Investigative ophthalmology & visual science · 2026Article
- Collagen microarchitecture from polarized light imaging: a biomechanics perspective.Journal of biomedical optics · 2026Review
- Non-linear interactions between intraocular, intracranial pressure and the retinal vascular pulse amplitude in the Fourier domain.Scientific reports · 2025Article
- Polarization-Sensitive Optical Coherence Tomography Imaging of Posterior Staphyloma Edges in Eyes With High Myopia.Investigative ophthalmology & visual science · 2025Observational
- Multiscale analysis of equatorial sclera anisotropy: Revealing discrepancies in fiber orientation and mechanical properties.Science advances · 2025Article
- Morphological Comparison of Astrocytes in the Lamina Cribrosa and Glial Lamina.Investigative ophthalmology & visual science · 2025Article
- Whorl-Like Collagen Fiber Arrangement Around Emissary Canals in the Posterior Sclera.Investigative ophthalmology & visual science · 2025Article
- Ocular Biomechanical Responses to Long-Duration Spaceflight.IEEE open journal of engineering in medicine and biology · 2025Article
- Comparing IOP-Induced Scleral Deformations in the Myopic and Myopic Glaucoma Spectrums.Investigative ophthalmology & visual science · 2024Article
- Comparing continuum and direct fiber models of soft tissues. An ocular biomechanics example reveals that continuum models may artificially disrupt the strains at both the tissue and fiber levels.bioRxiv : the preprint server for biology · 2024Article
- Morphological comparison of astrocytes in the lamina cribrosa and glial lamina.bioRxiv : the preprint server for biology · 2024Article
- OCT Optic Nerve Head Morphology in Myopia IV: Neural Canal Scleral Flange Remodeling in Highly Myopic Eyes.American journal of ophthalmology · 2024Article
- Lamina Cribrosa Insertions Into the Sclera Are Sparser, Narrower, and More Slanted in the Anterior Lamina.Investigative ophthalmology & visual science · 2024Article
- Optical Coherence Tomographic Optic Nerve Head Morphology in Myopia III: The Exposed Neural Canal Region in Healthy Eyes-Implications for High Myopia.American journal of ophthalmology · 2024Article
- Fibrous finite element modeling of the optic nerve head region.Acta biomaterialia · 2024Article
- Direct measurements of collagen fiber recruitment in the posterior pole of the eye.Acta biomaterialia · 2024Article
- 2D or not 2D? Mapping the in-depth inclination of the collagen fibers of the corneoscleral shell.Experimental eye research · 2023Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Purpose: The purpose of this study was to leverage polarized light microscopy (PLM) to visualize the collagen fiber architecture of posterior pole and optic nerve head with micrometer-scale resolution and to identify and quantify major organizational components. Methods: Eight sheep posterior poles were cryosectioned and imaged using PLM. Collagen fiber orientation was determined by using custom scripts, and the resulting orientation maps were inspected and quantified to identify major structural elements and tested for differences in mean fiber orientation and anisotropy, using linear mixed effect models. Results: Images revealed an intricate organization of collagen fibers in the posterior pole. In the lamina cribrosa, interweaving fibers formed large knots and wrapped around nerve fiber pores, with beam insertions into the scleral canal wall that were either narrow and straight or wide. In the peripapillary sclera, three significantly different (P < 0.0001) components were identified: fibers oriented circumferentially proximal to the canal, radially in the innermost sclera, and unaligned with interweaving fibers. The radial fibers were between 60 and 180 μm thick, extending at least 3 mm from the canal. Conclusions: PLM revealed structural aspects of the lamina cribrosa and sclera that may have important biomechanical roles but that were previously unreported or not characterized quantitatively. In the lamina cribrosa, these roles included wide and narrow beam insertions and details of collagen fibers interweaving and wrapping around the pores. In the sclera, we described regions of circumferential, radial, and unaligned "random" fibers. Although there is consensus that circumferential fibers protect neural tissues by resisting canal expansion, the role of the radial fibers remains unclear.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.