ArticleInternational journal of environmental research and public health2017
Effects of Gender on the Association of Urinary Phthalate Metabolites with Thyroid Hormones in Children: A Prospective Cohort Study in Taiwan.
Article in International journal of environmental research and public health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- The impact of exposure to phthalates in thyroid function of children and adolescents: a systematic review.European journal of pediatrics · 2024Pooled it
- Association Between Diethylhexyl Phthalate Exposure and Thyroid Function: A Meta-Analysis.Thyroid : official journal of the American Thyroid Association · 2019Pooled it
- Phthalate exposure and lipid disruption in Taiwanese children: Insights from serum lipidomic approach.Journal of food and drug analysis · 2026Article
- Phthalates exposure and serum uric acid level in patients with Crohn's disease: A cross-sectional study.PloS one · 2026Article
- Relationship of urinary bisphenol A in childhood on thyroid hormone function in adolescents: a cohort study.PloS one · 2025Article
- Concentration levels of phthalate metabolites in wild boar hair samples.Scientific reports · 2024Article
- A physiologically based pharmacokinetic model of diethyl phthalates in humans.Environmental pollution (Barking, Essex : 1987) · 2024Article
- Association of diethylhexyl phthalate exposure with serum thyroid hormone levels: a systematic review and meta-analysis.American journal of translational research · 2024Review
- Associations of urinary metabolite concentrations of phthalates and phthalate replacements with body composition from mid-childhood to early adolescence.Environmental research · 2023Article
- Phthalates in Glass Window Films of Chinese University Dormitories and Their Associations with Indoor Decorating Materials and Personal Care Products.International journal of environmental research and public health · 2022Article
- Plasticizers: negative impacts on the thyroid hormone system.Environmental science and pollution research international · 2022Review
- A Correlational Analysis of Phthalate Exposure and Thyroid Hormone Levels in Common Bottlenose Dolphins (Animals : an open access journal from MDPI · 2022Article
- An overview of organic contaminants in indoor dust, their health impact, geographical distribution and recent extraction/analysis methods.Environmental geochemistry and health · 2022Review
- Analysis and health risk assessment of phthalate esters (PAEs) in indoor dust of preschool and elementary school centers in city of Tehran, Iran.Environmental science and pollution research international · 2021Article
- Autistic-like traits in laboratory rodents exposed to phthalic acid esters during early development - an animal model of autism?Physiological research · 2021Review
- Article
- Combined effects of di (2-ethylhexyl) phthalate and bisphenol A on thyroid hormone homeostasis in adolescent female rats.Environmental science and pollution research international · 2020Article
- Human Erythrocytes Exposed to Phthalates and Their Metabolites Alter Antioxidant Enzyme Activity and Hemoglobin Oxidation.International journal of molecular sciences · 2020Article
- Concentration of phthalate esters in indoor and outdoor dust in Kocaeli, Turkey: implications for human exposure and risk.Environmental science and pollution research international · 2020Article
- Associations between school lunch consumption and urinary phthalate metabolite concentrations in US children and adolescents: Results from NHANES 2003-2014.Environment international · 2018Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phthalates are considered endocrine disruptors. Our study assessed the gender-specific effects of phthalate exposure on thyroid function in children. In total, 189 Taiwanese children were enrolled in the study. One-spot urine and blood samples were collected for analyzing 12 phthalate metabolites in urine and thyroid hormones. The association between urinary phthalate metabolites and serum thyroid hormones was determined using a generalized linear model with a log link function; the children were categorized into groups for analysis according to the 33rd and 66th percentiles. The data were stratified according to gender and adjusted for a priori defined covariates. In girls, a positive association existed between urinary di-2-ethylhexyl phthalate (DEHP) metabolites (mono-(2-ethylhexyl) phthalate, mono-(2-ethyl-5-oxohexyl) phthalate, and mono-(2-ethyl-5-hydroxyhexyl) phthalate) and free thyroxine (T4). In boys, urinary dibutyl phthalate (DBP) metabolites (mono-i-butyl phthalate and mono-n-butyl phthalate) were positively associated with free triiodothyronine (T3). After categorizing each exposure into three groups, urinary DEHP metabolites were positively associated with free T3 levels in boys. Our results suggested that DEHP is associated with free T4 in girls and that DBP is associated with free T3 in boys. Higher DEHP metabolite concentrations exerted larger effects on free T3 in boys. These results reveal the gender-specific relationships between phthalate metabolites and thyroid hormones.
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