ArticleUpsala journal of medical sciences2017
Supernumerary human hair cells-signs of regeneration or impaired development? A field emission scanning electron microscopy study.
Article in Upsala journal of medical sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 16 citations in OpenAlex.
- The tympanic covering layer contributes to basilar membrane elasticity potentially influencing human frequency resolution and speech perception.Journal of anatomy · 2026Article
- The Ear in Subterranean Rodents Revisited: Cochlear Hair-Cell Populations in African Mole-Rats (Bathyergidae).Journal of morphology · 2025Article
- The cochlear apex demystified: Implications from synchrotron radiation phase-contrast imaging and microscopy for cochlear implantation.Journal of anatomy · 2025Article
- Distribution of Immune Cells Including Macrophages in the Human Cochlea.Frontiers in neurology · 2021Review
- Assessing fractional hair cell survival in archival human temporal bones.The Laryngoscope · 2020Article
- The use of nonhuman primates in studies of noise injury and treatment.The Journal of the Acoustical Society of America · 2019Review
- Human inner ear blood supply revisited: the Uppsala collection of temporal bone-an international resource of education and collaboration.Upsala journal of medical sciences · 2018Article
- Article
- Article
- The secondary spiral lamina and its relevance in cochlear implant surgery.Upsala journal of medical sciences · 2018Article
- Review
- Macrophages in the Human Cochlea: Saviors or Predators-A Study Using Super-Resolution Immunohistochemistry.Frontiers in immunology · 2018Article
- Review
- Molecular composition and distribution of gap junctions in the sensory epithelium of the human cochlea-a super-resolution structured illumination microscopy (SR-SIM) study.Upsala journal of medical sciences · 2017Article
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCurrent attempts to regenerate cochlear sensorineural structures motivate further inspection of the human organ of hearing. Here, we analyzed the supernumerary inner hair cell (sIHC), a possible sign of regeneration and cell replacement.
methodsHuman cochleae were studied using field emission scanning electron microscopy (FESEM; maximum resolution 2 nm) obtained from individuals aged 44, 48, and 58 years with normal sensorineural pure-tone average (PTA) thresholds (PTA <20 dB). The wasted tissue was harvested during trans-cochlear approaches and immediately fixed for ultrastructural analysis.
resultsAll specimens exhibited sIHCs at all turns except at the extreme lower basal turn. In one specimen, it was possible to image and count the inner hair cells (IHCs) along the cochlea representing the 0.2 kHz-8 kHz region according to the Greenwood place/frequency scale. In a region with 2,321 IHCs, there were 120 scattered one-cell losses or 'gaps' (5%). Forty-two sIHCs were present facing the modiolus. Thirty-eight percent of the sIHCs were located near a 'gap' in the IHC row (±6 IHCs).
conclusionsThe prevalence of ectopic inner hair cells was higher than expected. The morphology and placement could reflect a certain ongoing regeneration. Further molecular studies are needed to verify if the regenerative capacity of the human auditory periphery might have been underestimated.
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