Evidence map›Paper›PMID 28145571›Full record

ArticleJournal of medical primatology2017

A significant productive in vivo infection of resting cells with simian immunodeficiency virus in a macaque with AIDS.

Bapi Pahar, Wendy Lala, Dot Kuebler, David Liu

Abstract readCase Reports
In one paragraph

Article in Journal of medical primatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Bapi PaharDivision of Comparative Pathology, Tulane National Primate Research Center, Covington, LA, USA.
Wendy LalaDivision of Comparative Pathology, Tulane National Primate Research Center, Covington, LA, USA.
Dot KueblerDivision of Comparative Pathology, Tulane National Primate Research Center, Covington, LA, USA.
David LiuDivision of Comparative Pathology, Tulane National Primate Research Center, Covington, LA, USA.

Funding

Tulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4M
Center for Experimental Infectious Disease ResearchP20GM103458 · NIGMS · LOUISIANA STATE UNIV A&M COL BATON ROUGE · PI KOUSOULAS, KONSTANTIN G · 2012 to 2013
$4.5M
Importance of antigen specific immunoglobulin responses in controlling SIV/SHIV iR21AI080395 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI PAHAR, BAPI · 2009 to 2010
$454k
NIAID NIH HHS R21 AI080395NIGMS NIH HHS P20 GM103458NIH HHS P51 OD011104
6 · The paper itself

Abstract

Identifying the cells that can be infected with HIV in vivo and thus potentially persist as latent reservoirs is of high priority. Here, we report the major infected cells in a chronically simian immunodeficiency virus (SIV)-infected macaque that developed AIDS and encephalitis. A majority of the infected cells were detected as non-proliferating resting cells. SIV-infected non-proliferating resting cells were found to be playing an important role in viral pathogenesis, persistence, or reservoir formation.

Indexed as

Macaca mulattaAnimalsDendritic CellsEncephalitisMacrophagesMaleSimian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusT-Lymphocytesinfectionmacrophagereservoirresting cellssimian immunodeficiency virussimian immunodeficiency virus RNAT cells

Identifiers

PMID28145571
PMCPMC5359019

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.