ArticleScientific reports2017
Intracellular Accumulation of Gold Nanoparticles Leads to Inhibition of Macropinocytosis to Reduce the Endoplasmic Reticulum Stress.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Green synthesis of spheroid silver nanoparticles using cyanobacteria with multifunctional biological activities.Scientific reports · 2026Article
- Time-point-based analysis of gold nanoparticles in MCF-7 cells following ultrasound irradiation: quantitative and label-free intracellular characterization.Nanoscale advances · 2026Article
- Smartphone-Compatible Colorimetric Detection of CA19-9 Using Melanin Nanoparticles and Deep Learning.Biosensors · 2025Article
- Selenium Nanoparticles as Neuroprotective Agents: Insights into Molecular Mechanisms for Parkinson's Disease Treatment.Molecular neurobiology · 2025Review
- Comparison of Drug Delivery Systems with Different Types of Nanoparticles in Terms of Cellular Uptake and Responses in Human Endothelial Cells, Pericytes, and Astrocytes.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Gold Nanoparticles (AuNPs)-Toxicity, Safety and Green Synthesis: A Critical Review.International journal of molecular sciences · 2024Review
- Probing the Cellular Fate of the Protein Corona around Nanoparticles with Nanofocused X-ray Fluorescence Imaging.International journal of molecular sciences · 2023Article
- Nanocomposite Materials Based on Polylactide and Gold Complex Compounds for Absorbed Dose Diagnostics in BNCT.International journal of molecular sciences · 2023Article
- Exploring nanocomposites for controlling infectious microorganisms: charting the path forward in antimicrobial strategies.Frontiers in pharmacology · 2023Review
- Review
- Mechanisms of Silver Nanoparticle Uptake by Embryonic Zebrafish Cells.Nanomaterials (Basel, Switzerland) · 2021Article
- Ionic gold demonstrates antimicrobial activity against Pseudomonas aeruginosa strains due to cellular ultrastructure damage.Archives of microbiology · 2021Article
- Chitosan-Coated Gold Nanoparticles Induce Low Cytotoxicity and Low ROS Production in Primary Leucocytes, Independent of Their Proliferative Status.Pharmaceutics · 2021Article
- Screening for Effects of Inhaled Nanoparticles in Cell Culture Models for Prolonged Exposure.Nanomaterials (Basel, Switzerland) · 2021Article
- Current update on nanoplatforms as therapeutic and diagnostic tools: A review for the materials used as nanotheranostics and imaging modalities.Asian journal of pharmaceutical sciences · 2021Review
- Antibacterial and Anticancer Potentials of Presynthesized PhotosensitiveBioinorganic chemistry and applications · 2021Article
- Uptake quantification of gold nanoparticles inside of cancer cells using high order image correlation spectroscopy.Biomedical optics express · 2021Article
- Endoplasmic Reticulum Stress Provocation by Different Nanoparticles: An Innovative Approach to Manage the Cancer and Other Common Diseases.Molecules (Basel, Switzerland) · 2020Review
- Understanding the influence of experimental factors on bio-interactions of nanoparticles: Towards improving correlation between in vitro and in vivo studies.Archives of biochemistry and biophysics · 2020Review
- Direct Conjugation of Retinoic Acid with Gold Nanoparticles to Improve Neural Differentiation of Human Adipose Stem Cells.Journal of molecular neuroscience : MN · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding the toxicity of nanomaterials remains largely limited to acute cellular response, i.e., short-term in vitro cell-death based assays, and analyses of tissue- and organ-level accumulation and clearance patterns in animal models, which have produced very little information about how these materials (from the toxicity point of view) interact with the complex intracellular machinery. In particular, understanding the mechanism of toxicity caused by the gradual accumulation of nanomaterials due to prolonged exposure times is essential yet still continue to be a largely unexplored territory. Herein, we show intracellular accumulation and the associated toxicity of gold nanoparticles (AuNPs) for over two-months in the cultured vascular endothelial cells. We observed that steady exposure of AuNPs at low (non-lethal) dose leads to rapid intracellular accumulation without causing any detectable cell death while resulting in elevated endoplasmic reticulum (ER) stress. Above a certain intracellular AuNP threshold, inhibition of macropinocytosis mechanism ceases further nanoparticle uptake. Interestingly, the intracellular depletion of nanoparticles is irreversible. Once reaching the maximum achievable intracellular dose, a steady depletion is observed, while no cell death is observed at any stage of this overall process. This depletion is important for reducing the ER stress. To our knowledge, this is the first report suggesting active regulation of nanoparticle uptake by cells and the impact of long-term exposure to nanoparticles in vitro.
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