ArticleScientific reports2017
ZP3 is Required for Germinal Vesicle Breakdown in Mouse Oocyte Meiosis.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- Genome-Wide Identification and Expression Analysis of Zona Pellucida (ZP) Gene Family inInternational journal of molecular sciences · 2025Article
- A novel mutation in ZP3 causes human ovulatory dysfunction and oocyte maturation arrest.Journal of ovarian research · 2025Article
- Protein-targeting reverse genetic approaches: the future of oocyte and preimplantation embryo research.Molecular human reproduction · 2025Review
- Unraveling the mysteries of early embryonic arrest: genetic factors and molecular mechanisms.Journal of assisted reproduction and genetics · 2024Review
- A framework for identifying fertility gene targets for mammalian pest control.Molecular ecology resources · 2024Article
- Comparative Transcriptome Analysis Reveals Sexually Dimorphic Gene Expression in the Gonads ofAnimals : an open access journal from MDPI · 2023Article
- Intracellular fraction of zona pellucida protein 3 is required for the oocyte-to-embryo transition in mice.Molecular human reproduction · 2023Article
- The Novel Role ofInternational journal of molecular sciences · 2023Article
- Transfer of theZoological research · 2023Article
- Case report: A novel homozygous variant in ZP3 is associated with human empty follicle syndrome.Frontiers in genetics · 2023Article
- Review
- The proteome, not the transcriptome, predicts that oocyte superovulation affects embryonic phenotypes in mice.Scientific reports · 2021Article
- Context-dependent functional compensation between Ythdf mGenes & development · 2020Article
- Identification of critical sex-biased genes in Andrias davidianus by de novo transcriptome.Molecular genetics and genomics : MGG · 2019Article
- Transcriptome analysis of rhesus monkey failed-to-mature oocytes: deficiencies in transcriptional regulation and cytoplasmic maturation of the oocyte mRNA population.Molecular human reproduction · 2018Article
- A Recurrent Missense Mutation in ZP3 Causes Empty Follicle Syndrome and Female Infertility.American journal of human genetics · 2017Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ZP3 is a principal component of the zona pellucida (ZP) of mammalian oocytes and is essential for normal fertility, and knockout of ZP3 causes complete infertility. ZP3 promotes fertilization by recognizing sperm binding and activating the acrosome reaction; however, additional cellular roles for ZP3 in mammalian oocytes have not been yet reported. In the current study, we found that ZP3 was strongly expressed in the nucleus during prophase and gradually translocated to the ZP. Knockdown of ZP3 by a specific siRNA dramatically inhibited germinal vesicle breakdown (GVBD) (marking the beginning of meiosis), significantly reducing the percentage of MII oocytes. To investigate the ZP3-mediated mechanisms governing GVBD, we identified potential ZP3-interacting proteins by immunoprecipitation and mass spectrometry. We identified Protein tyrosine phosphatase, receptor type K (Ptprk), Aryl hydrocarbon receptor-interacting protein-like 1 (Aipl1), and Diaphanous related formin 2 (Diaph2) as potential candidates, and established a working model to explain how ZP3 affects GVBD. Finally, we provided preliminary evidence that ZP3 regulates Akt phosphorylation, lamin binding to the nuclear membrane via Aipl1, and organization of the actin cytoskeleton via Diaph2. These findings contribute to our understanding of a novel role played by ZP3 in GVBD.
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