ArticleNature communications2017
Serotonin-dependent kinetics of feeding bursts underlie a graded response to food availability in C. elegans.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed.
- The Marginal Value Theorem inbioRxiv : the preprint server for biology · 2026Article
- PumpKin: A machine-learning pipeline for automatically tracking localized kinematics in freely moving C. elegans.PLoS computational biology · 2026Article
- Metabolic state modulates risky foraging behavior via multiple branches of the insulin/IGF-1-like pathway in C. elegans.G3 (Bethesda, Md.) · 2026Article
- Coffee Silverskin Supplementation Alleviates High-Glucose-Diet-Induced Obesity by Modulating Lipogenic Gene Expression inMolecules (Basel, Switzerland) · 2026Article
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- Hungry for Knowledge: Octopamine Signaling Regulates Hunger-Enhanced Olfactory Learning.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Context-dependent serotonin signaling links dietary quality to foraging decisions.Nature communications · 2025Article
- Gut epithelium modifies enteric behaviors during nutritional adversity via distinct peptidergic signaling axes.Science advances · 2025Article
- EZ-FRCNN: A Fast, Accessible and Robust Deep Learning Package for Object Detection Applications from Ethology to Cell Biology.bioRxiv : the preprint server for biology · 2025Article
- Esculetin Inhibits Fat Accumulation Through Insulin/Insulin-like Growth Factor- and AMP-Activated Protein Kinase-Dependent Pathways inNutrients · 2025Article
- Reduced adult stem cell fate specification led to eye reduction in cave planarians.Nature communications · 2025Article
- Article
- High-Resolution Imaging and Morphological Phenotyping ofResearch (Washington, D.C.) · 2024Article
- Dolutegravir-induced growth and lifespan effects in Caenorhabditis elegans.BMC pharmacology & toxicology · 2023Article
- Caenorhabditis elegans foraging patterns follow a simple rule of thumb.Communications biology · 2023Article
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- The nematode wormeLife · 2023Article
- Article
- Regulation and modulation of biogenic amine neurotransmission inFrontiers in physiology · 2023Review
- Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Animals integrate physiological and environmental signals to modulate their food uptake. The nematode C. elegans, whose food uptake consists of pumping bacteria from the environment into the gut, provides excellent opportunities for discovering principles of conserved regulatory mechanisms. Here we show that worms implement a graded feeding response to the concentration of environmental bacteria by modulating a commitment to bursts of fast pumping. Using long-term, high-resolution, longitudinal recordings of feeding dynamics under defined conditions, we find that the frequency and duration of pumping bursts increase and the duration of long pauses diminishes in environments richer in bacteria. The bioamine serotonin is required for food-dependent induction of bursts as well as for maintaining their high rate of pumping through two distinct mechanisms. We identify the differential roles of distinct families of serotonin receptors in this process and propose that regulation of bursts is a conserved mechanism of behaviour and motor control.
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